厄贝沙坦与培哚普利对非杓型高血压昼夜节律近期干预效应的临床观察被引量：10

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摘要目的比较厄贝沙坦与培哚普利对非杓型高血压患者血压昼夜节律的近期干预效应。方法应用随机数字表将82例非杓型高血压患者分为A、B两组(每组各41例):两组于每日7点分别服用厄贝沙坦片、培哚普利片;随访12周,于治疗前及治疗后4周、12周进行24小时动态血压检查,以平均动脉压(MAP)作为判断血压变化的衡量指标,计算并比较两组的诊室白昼MAP下降均值、夜间MAP下降均值、24小时MAP达标率、白昼MAP达标率、夜间MAP达标率、杓型血压转变率。结果①治疗后各时点两组的白昼MAP、夜间MAP均值均较治疗前明显降低,自身前后比较差异均有显著性(P<0.01);②治疗4周后A组各项指标略大于或高于B组,但差异均无显著性(P>0.05);③治疗12周后A组的夜间MAP下降均值、夜间MAP达标率、杓型血压转变率大于或高于B组,且差异均有显著性(P<0.05)。结论厄贝沙坦对非杓型高血压患者的血压昼夜节律的近期干预效应优于培哚普利,两者对非杓型高血压患者血压昼夜节律的近期干预效应的差异主要体现在对患者夜间血压的干预。

作者樊英

机构地区湖北省公安县甘家厂乡卫生院内科

出处《中国临床医生杂志》 2013年第3期47-48,共2页 Chinese Journal For Clinicians

关键词厄贝沙坦培哚普利高血压原发性非杓型昼夜节律

分类号 R544.1 [医药卫生—心血管疾病]

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