摘要
近十年来,关于骨髓瘤细胞的分子生物学研究取得了很大的进展。骨髓瘤细胞通过激活多种信号途径以及与蛋白折叠反应相关的信号通路,抑制正常浆细胞的生长。一些基因和分子改变与临床表现相关并成为治疗的潜在靶点。认识骨髓瘤细胞的分子生物学特性对于采取合理的治疗措施、改善患者的预后至关重要。
There has been immense progress in the understanding of the molecular biology of myeloma during the last decade. Many of the molecular features of myeloma modify and hijack key normal plasma cell growth and survival pathways to ensure the growth of myeloma cells. Active pathways include pathways, as well as protein turnover. Some genetic and molecular lesions are linked with distinct clinical outcomes or represent potential therapeutic targets.An under-standing of the molecular biology of myeloma, therefore, is important for informing rationale treatment decisions and improving patient outcome.
出处
《医学与哲学（B）》
2013年第2期58-61,共4页
Medicine & Philosophy(B)
基金
山东省自然科学基金课题
项目编号:Y2007C103
关键词
多发性骨髓瘤
分子生物学
靶向治疗
multiple myeloma, molecular biology, targeted therapy
