A Formal Synthesis of Iridoid 9-Deoxygelsemide

A Formal Synthesis of Iridoid 9-Deoxygelsemide

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摘要 A formal total synthesis of iridoid 9-deoxygelsemide has been accomplished. Our approach features the use of （S）-carvone as starting material, Favorskii rearrangement to construct the functionalized cyclopentane core, Chugeav elimination to introduce the endocyclic double bond, and the ring-opening reaction of epoxide to build the second five-membered ring. A formal total synthesis of iridoid 9-deoxygelsemide has been accomplished. Our approach features the use of （S）-carvone as starting material, Favorskii rearrangement to construct the functionalized cyclopentane core, Chugeav elimination to introduce the endocyclic double bond, and the ring-opening reaction of epoxide to build the second five-membered ring.

作者 Yang Liu Gang Zhao

机构地区 Key Laboratory of Synthetic Chemistry of Natural Substances

出处《Chinese Journal of Chemistry》 SCIE CAS CSCD 2013年第1期18-22,共5页 中国化学（英文版）

关键词 IRIDOID 9-deoxygelsemide Favorskii rearrangement Chugeav elimination iridoid, 9-deoxygelsemide, Favorskii rearrangement, Chugeav elimination

分类号 TQ174.758 [化学工程—陶瓷工业] O624.33 [理学—有机化学]

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Chinese Journal of Chemistry

2013年第1期

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A Formal Synthesis of Iridoid 9-Deoxygelsemide

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