摘要
目的评价陕西省铜川市百日咳-白喉-破伤风联合疫苗的免疫效果,为制定有效的免疫策略提供参考依据。方法用酶联免疫吸附试验方法检测适龄儿童全程免疫接种百白破疫苗前后百日咳、白喉、破伤风IgG抗体水平。结果全程免疫接种后,百日咳抗体阳转率为88.59%,抗体几何平均浓度(geometry mean concentration,GMC)增加了16倍;白喉抗体阳转率为100%,平均GMC增加了130倍;破伤风抗体阳转率为100%,平均GMC增加了57倍。结论百白破疫苗免疫效果良好,但百日咳菌苗免疫持久性较差。
Objective To evaluate the immunization effect of DPT vaccine in health population in Tongchuan, Shaanxi province, and provide scientific evidence for the development of effective immunization strategy of DPT. Methods Enzyme-linked immunosorbent assay （ELISA） was conducted to detect pertussis, diphtheria, tetanus IgG antibody levels in school-aged children before and after DPT vaccination. Results After full vaccination, the pertussis antibody positive conversion rate was 88. 59%, the antibody＇ s geometric mean concentration （GMC） increased by 16 times; the diphtheria antibody positive conversion rate was 100% , the GMC increased by 130 times; the tetanus antibody positive conversion rate was 100% , the GMC increased by 57 times. Conclusion The DPT vaccination was successful in Tongchuan, but the duration of pertussis vaccine protection was short.
出处
《疾病监测》
CAS
2013年第2期109-111,共3页
Disease Surveillance
基金
铜川市科学技术研究发展计划项目(No.KJ2011-03)~~
关键词
百白破疫苗
免疫成功率
监测
DPT vaccine
immunization rate
surveillance
