摘要
为了解急性脑梗塞患者的凝血、抗凝及纤溶状态 ,对 3 0例急性脑梗塞患者在急性期及恢复期测定血浆AT -Ⅲ :A、AT -Ⅲ :Ag、t -PA :A、PAI :A、FPA、DD ,结果显示 :急性脑梗塞患者在急性期AT -Ⅲ :Ag低于正常对照组 ( P <0 .0 5 ) ,PAI :A含量明显高于正常对照组 (P <0 .0 1) ,而t -PA :A含量则明显低于正常对照组 (P <0 .0 1)。FPA、DD在急性期及恢复期均高于正常对照组。FPA在发病后即有明显增高。认为急性脑梗塞患者凝血、抗凝及纤溶活性改变在血栓形成的发病机理中具有重要意义 ,血浆AT -Ⅲ :Ag、t-PA :A、PAI :A、FPA、DD含量的测定可作为急性脑梗塞患者客观血液学指标 ,为急性脑梗塞的治疗及病情演变的观察提供了依据。
In order to study the state of blood coagulation, anti-blood coagulation and fibrinolysis, the plasma AT-Ⅲ: A, AT-Ⅲ: Ag, t-PA:A, FPA, and DD from 30 patients with acute cerebral infarction in acute and recovery stage were determined. Results showed that the AT-Ⅲ:Ag in acute stage was lower than the normal control group (P<0.05). The content of PAI:A significantly higher than the normal control group (P<0.01), but the content of t-PA:A was obviously lower than the normal control group (P<0.01). Both FPA and DD in acute and recovery stage were higher than normal control group. FPA increased significantly after the attack of illness. It indicated that the blood coagulation, anti-blood coagulation and the change of fibrinolytic activity played an important role in the mechanism of thrombosis. The content determination of plasma AT-Ⅲ:Ag, t-PA:A, PAI:A, FPA and DD may act as the objective blood rheology index in patients with acute cerebral infarction, for they offered the data to treat of acute cerebral infarction and to observe the development of the illness.
出处
《右江民族医学院学报》
2000年第4期525-527,共3页
Journal of Youjiang Medical University for Nationalities
关键词
脑梗塞
抗凝血酶Ⅲ
组织型纤溶酶原激活物
纤溶
cerebral infarction
antithrombinⅢ
histomorphologic plasminogen activator
fibrinopeptide A
D-dimer
