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鼻咽部低级别乳头状腺癌1例临床病理学观察 被引量：13

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摘要 目的观察鼻咽部低级别乳头状腺癌(low grade papil-lary adenocarcinoma of the nasopharynx,LGPACNP)的临床病理学特点,探讨其免疫表型及鉴别诊断。方法对1例LG-PACNP进行组织形态学观察及免疫组化标记,追踪随访患者的预后,并复习相关文献。结果患者女性,40岁。肿瘤组织主要由树枝状乳头和管状腺体组成,部分区域呈梭形,乳头可见纤维血管轴心,腺体不规则,呈囊性、管状、梭形、乳头和管腔表面被覆单层柱状或假复层柱状上皮。免疫表型:瘤细胞CK(AE1/AE3)、CK7、vimentin、TTF-1均阳性,TG、S-100均阴性。结论原发性LGPACNP是一种罕见的、具有明确形态学特征的低度恶性上皮性肿瘤,免疫组化标记有助于肿瘤的诊断,应与其它形态学相似的肿瘤鉴别;肿瘤完整切除可取得良好疗效。
作者 韩庶勇 杨飞 袁传涛 张仁亚
机构地区 山东省单县东大医院病理科 山东省成武县人民医院病理科 济宁医学院附属医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第3期328-330,共3页 Chinese Journal of Clinical and Experimental Pathology
关键词 鼻咽部肿瘤 乳头状腺癌 低级别 免疫组织化学
分类号 R739.6 [医药卫生—肿瘤]
  • 相关文献

参考文献18

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二级参考文献21

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共引文献7

同被引文献67

  • 1Barnes L, Eveson JW, Reichart P, et al. WHO classification of tumors. Pathology and genetics of head and neck tumors [ M]. Lyon: IARC Press, 2005.
  • 2Wenig BM, Hyams VJ, Heffner DK. Nasopharyngeal papillary adenocarcinoma. A clinicopathologic study of a low-grade carcinoma [J]. Am J Surg Pathol, 1988, i2(12) : 946-955.
  • 3Pineda-Daboin K, Neto A, Ochoa-Perez V, et al. Nasopharyngeal adenocarcinomas: a clinicopathologic study of 44 cases including immunohistochemical features of 18 papillary phenotypes[ J]. Ann Oiagn Pathol, 2006, 10(4) : 215-221.
  • 4van Hasseh CA, Ng HK. Papillary adenocarcinoma of the nasopharynx[J]. J Laryngol Otot, 1991, 105(10) : 853-854.
  • 5Nojeg MM, Jalaludin MA, Jayalakshmi P. Papillary adenocarcinoma of the nasopharynx--case report and review of the literature[ J]. Med J Malaysia, 1998, 53 ( 1 ) : 104-106.
  • 6Carrizo F, Luna MA. Thyroid transcription factor-1 expression in thyroid-like nasopharyngeal papillary adenocarcinoma: report of 2 cases[J]. Ann Diagn Pathol, 2005, 9(4) : 189-192.
  • 7Wu PY, Huang CC, Chen HK, et al. Adult thyrold-like low- grade nasopharyngeal papillary adenocarcinoma with thyroid transcription factor-1 expression[ J]. Otolaryngol Head Neck Surg, 2007, 137(5): 837-838.
  • 8Sillings CN, Weathers DR, Delgaudio JM. Thyroid-like papillary adenocarcinoma of the nasopharynx: a case report in a 19-year-oldmale[Jl. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010, 110(3): e25-e28.
  • 9Petersson F, Pang B, Loke D, et al. Biphasic low-grade nasopharyngeal papillary adenocarcinoma with a prominent spindle cell component: report of a case localized to the posterior nasal septum[Jl. Head Neck Pathol, 2011, 5(3) : 306-313.
  • 10Fu CH, Chang KP, Ueng SH, et al. Primary thyroid-like papillary adenocarcinoma of the nasopharynx [ J ]. Auris Nasus Larynx, 2008, 35(4) : 579-582.

引证文献13

二级引证文献33

临床与实验病理学杂志
2013年 第3期

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