摘要
目的探讨慢性丙型肝炎患者体内血清谷氨酸脱羧酶抗体水平对干扰素治疗丙型肝炎疗效的影响。方法选择2007—2011年收治的慢性丙型肝炎患者66例,按照血清谷氨酸脱羧酶抗体水平分为2组,A组34例,B组32例,均给予α-干扰素治疗,疗程为48周,治疗后对2组患者肝功能、丙型肝炎病毒转阴率、活性T淋巴细胞水平以及干扰素应答率进行比较。结果 B组患者治疗后丙型肝炎病毒转阴率为84.4%,持久病毒学应答率为59.4%,均显著好于A组(P<0.05),且治疗后B组在肝功能、T淋巴细胞水平变化也显著好于A组(P<0.05)。结论慢性丙型肝炎患者体内血清谷氨酸脱羧酶抗体水平是糖耐量和免疫机制受到损害的体现,可影响干扰素的作用机制,降低其治疗丙型肝炎的临床效果。
Objective To investigate the effect of glutamic acid decarboxy/ase antibody on interferon in treating patients with chronic hepatitis C. Methods Sixty-six patients with chronic hepatitis C in Tangshan Yutian Hospital and the Fifth Hospital of Shijiazhuang were selected and divided into two groups by the level of glutamic acid decarboxylase antibody ： group A （ n = 34） and group B （ n = 32）, and all the patients were given interferon for 48 weeks, the liver function, negative rate of HCV-RNA, T lymphocyte level and non-response rate of interferon were compared after treatment. Results Hepatitis C virus negative rate of group B patients after treatment was 84.4%, and durable virologic response rate was 59.4%, which were significantly better than those of group A （P 〈 0. 05 ）, and after treatment liver function and T lymphocyte levels of group B was also significantly better than those of group A （P 〈 0. 05）. Conclusion Glutamic acid decarboxylase antibody is an important clinical damage indicator of glucose tolerance and immunity, and also can affect the mechanism of interferon and lower its clinical effect in treating chronic hepatitis C.
出处
《河北医科大学学报》
CAS
2013年第2期137-139,共3页
Journal of Hebei Medical University
关键词
肝炎
丙型
干扰素Α
治疗结果
hepatitis C
interferon-alpha
treatment outcome＇
