摘要
目的初步评价加巴喷丁添加治疗难治性部分性癫痫的疗效及安全性。方法采用RevMan5.0软件对纳入文献的相关数据进行Meta分析。结果加巴喷丁组发作频率减少及增加的比例与安慰剂组相比,差异均具有统计学意义。发作频率减少≥50%的OR为2.17,95%CI为1.53～3.07;50%≤发作频率减少<75%的OR为1.87,95%CI为1.02～3.44;发作频率减少≥75%的OR为2.16,95%CI为1.16～4.03。发作频率增加的OR为0.57,95%CI为0.40～0.81。加巴喷丁组因不良反应退出的比例及部分不良反应发生率与安慰剂组相比,差异具有统计学意义。结论加巴喷丁添加治疗难治性部分性癫痫的疗效高于安慰剂,部分不良反应发生率高于安慰剂。
Objective To evaluate the clinical efficacy and safety of gabapentin as add-on therapy in treatment of re- fractory partial epilepsy. Methods Based on the data provided by included literatures, meta-analysis was conducted by software RevMan 5.0. Results Seizure reduction and increase of gabapentin group were different from that of placebo group,which were statistically significant. The OR of seizure reductions〉50% was 2.17（95% CI was 1.53 -3.07 ） ,the OR of 50% ≤ seizure reduction 〈 75% was 1.87 （ 95% CI was 1.02 - 3.44） , the OR of seizure reduction ≥ 75% was 2.16 （95 % CI was 1.16 - 4.03 ） , and the OR of seizure increase was 0.57 （ 95 % CI was 0.40 - 0.81 ）. The withdrawal propor- tion because ofderived from adverse event and incidence of some adverse event of gabapentin group were different from that of placebo group,which were statistically significant. Conclusion Clinical efficacy of gabapentin as add-on therapy is sig- nificantly better than that of placebo in treatment of refractory partial epilepsy. But the incidence of some adverse event in- duced by gabapentin is higher than placebo.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2013年第2期148-150,共3页
Journal of Apoplexy and Nervous Diseases
