摘要
干扰素是一类由不同细胞产生的可溶性糖蛋白,并且具有抗病毒,抗肿瘤和免疫调节功能。目前,干扰素已被用于治疗多种疾病,包括毛细胞白血病、乙型肝炎、丙型肝炎以及其他治疗领域。然而,这种治疗的缺点是干扰素在血液中的短半衰期以及快速被清除。近年来,有资料已证明聚乙二醇(PEG)共轭结合生物分子比其相应的未修饰分子表现出优越的临床应用。然而,虽然蛋白共轭连接聚乙二醇能够延长它们在血液中的半衰期,但是通常会导致生物学和药理学活性的急剧降低甚至活性丧失。在此,对干扰素及其聚乙二醇修饰产物的药理学、药代动力学以及药效进行对比概述。
Interferons are a family of soluble glycoproteins produced by different cells and exhibit antiviral, antitumor and immunomodulation functions. At present they have been used to treat many diseases including hairy-cell leukemia and hepatitis B and C and have been applied to other therapeutic areas. A drawback to the therapy however, is the short serum half-life and rapid clearance of the interferon protein. In recent years, polyethylene glycol （PEG） conjugated biomolecules have been shown to exhibit superior clinically useful properties than their corresponding unmodified parent molecules. However, while the covalent attachment of PEG chains to proteins prolongs their lifetime in vivo, it often results in a dramatic reduction or even loss of biological and pharmacological activities. Herein the pharmacology, pharmacokinetics and pharmacodynamics of interferon and its PEGylated products were compared.
出处
《现代生物医学进展》
CAS
2013年第3期587-589,共3页
Progress in Modern Biomedicine
关键词
干扰素
聚乙二醇
药理学
药代动力学
药效
Interferon
Polyethylene
Pharmacology
Pharmacokinetics
Pharmacodynamics
