摘要
目的:《伤寒论》中大承气汤的煎煮古法"以水一斗,先煮二物(厚朴、枳实),取五升,去滓,纳大黄,更煮取二升,去滓,纳芒硝,更上微火一两沸",其中厚朴、枳实先煎后需去渣,该文旨在研究蒽醌类成分的含量,以考察去厚朴、枳实二物药渣的科学性。方法:采用传统煎煮方法煎煮大承气汤,A汤剂(原法)去厚朴、枳实药渣,B汤剂不去厚朴、枳实药渣,采用HPLC测定2份汤剂及药渣中大黄结合蒽醌、游离蒽醌的含量。结果:A汤剂中结合蒽醌、游离蒽醌均较B汤剂含量高,A药渣总蒽醌含量低于B药渣。结论:大承气汤古法煎煮方式去厚朴、枳实药渣的科学性,就在于提高了有效成分的溶出率,为其药效物质基础提供了理论依据。
Objective： The traditional decoction method of Dachengqi Tang is that ＂First boiling Magnolia officinalis and Cit- rus aurantium with a pipeful of water, taking out five litres from the decoction, removing residues, adding rheum officinale, boiling again, taking out two litres from it, removing residues, adding mirabilite, boiling it with low fire＂. According to it, residues of M. officinalis and C. aurantium should be removed after decocting. This essay aims to study the content of anthraquinones, in order to proof whether the removal of residues of M. officinalis and C. aurantium is scientific. Method ： The traditional method was adopted to pre- pare Dachengqi Tang. Decoction A （original method） was obtained by removing residues of M. officinalis and C. aurantium, whereas decoction B was obtained without removing residues of M. officinalis and C. aurantium. The content of anthraquinones of both methods was determined with HPLC. Result： The content of both combined and free anthraquinones in decoction A was higher than that of de- coction B. The content of total anthraquinones in residues of decoction A was lower than that of residue B. Conclusion： The traditional decoction method of removing residues of M. officinalis and C. aurantium from Dachengqi Tang is scientific, because it improves the dissolution rate of effective ingredients, which provides a theoretical basis for effective substances of the drug.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第5期694-697,共4页
China Journal of Chinese Materia Medica
基金
国家重点基础研究发展计划(973)项目(2010CB530602)
关键词
大承气汤
药渣
结合蒽醌
游离蒽醌
总蒽醌
含量测定
Dachengqi Tang
residue
combined anthraquinones
free anthraquinones
total anthraquinones
determination ofcontent
