摘要
目的探讨非霍奇金淋巴瘤化疗后肺部感染患者体液免疫、细胞免疫及炎性因子的变化规律,为临床诊断及治疗提供依据。方法选取2010年1月-2012年6月医院治疗的24例非霍奇金淋巴瘤化疗后肺部感染患者为观察组,同期未发生肺部感染的24例患者为对照组,将两组患者体液免疫、细胞免疫及炎性因子水平进行比较。结果观察组的IgA、IgG及IgM分别为(1.13±0.14)g/L、(8.05±1.07)g/L及(1.08±0.10)g/L,均低于对照组,CD3+、CD4+及CD4/CD8比值分别为(66.24±3.78)%、(39.25±2.86)%及0.92±0.19,均低于对照组,CD8+为(42.15±3.81)%,高于对照组,血清IL-6、IL-8、IL-10、CRP及TNF-α分别为(77.35±7.21)pg/ml、(30.39±2.93)pg/ml、(228.63±21.48)pg/ml、(8.14±0.97)mg/L及(75.46±6.93)pg/ml,均高于对照组,且重度感染患者变化幅度大于轻度及中度患者,差异有统计学意义(P<0.05)。结论非霍奇金淋巴瘤化疗后肺部感染患者体液免疫、细胞免疫均处于较差的状态,而炎性因子处于较高的状态。
OBJECTIVE To study the variation of humoral immune, cellular immunity and inflammatory factors of the patients with non-hodgkin＇s lymphoma and pulmonary infections after the chemotherapy so as to provide the evidence for the clinical diagnosis and treatment. METHODS Totally 24 patients with non-hodgkin＇s lymphoma and pulmonary infections who underwent the chemotherapy in the hospital from Jan 2010 to Jun 2012 were selected as the observation group, and in the same period 24 patients without pulmonary infections were selected as the control group,then the humoral immune, cellular immunity and inflammatory factors of the two groups were compared. RESULTS The IgA,IgG and IgM of the observation group were （1.13±0.14）g/L,（8.05±1.07）g/L and （1.08± 0.10）g/L, respectively, lower than those of the control group. The CD3＋, CD4＋ and CD4/CD8 of the control group were （66.24±3. 78）%, （39.25±2. 86）% and 0. 92±0. 19,respectively, lower than those of the control group; the CD8 ＋ of the observation group was （42.15±3.81）% ,higher than that of the control group ; the serum IL-6, IL-8, IL-10, CRP and TNF-a of the observation group were （77. 35 ± 7.21） pg/ml, （30. 39 ± 2.93） pg/ml, （228.63 ± 21.48） pg/ml, （8. 14 ± 0. 97） mg/L and（75.46 ± 6. 93） pg/ml, respectively, higher than those of the control group, and the changes of patients with severe infections were greater than those with slight or moderate infections,the difference was statistically significant （P〈0. 05）. CONCLUSION The humoral immune and the celluar immunity of the patients with non-hodgkin＇s lymphoma and pulmonary infections are in a poor state after the chemotherapy, but the inflammatory factor are in a high state.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第6期1259-1261,共3页
Chinese Journal of Nosocomiology
关键词
非霍奇金淋巴瘤
肺部感染
体液免疫
细胞免疫
炎性因子
Non-hodgkin＇s lymphoma
Pulmonary infection
Humoral immune
Cellular immunity
Inflammatory factor
