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甲巯咪唑引起粒细胞缺乏症 被引量:2

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摘要 患者,男性,45岁,慢性乙肝(重度)合并肺部感染,住院期间因"甲状腺功能亢进"使用初始剂量为"30 mg/d"的甲巯咪唑治疗,1个半月后实验室检查甲状腺功能指标逐渐好转,剂量减为"15 mg/d"。用药期间定期复查血常规,前期未发现异常情况,但用药2个月时连续2次隔日复查血常规均提示白细胞明显减少伴中性粒细胞缺乏,最低至白细胞0.58×109/L(中性粒细胞百分率6.9%);并出现高热、畏寒、寒战、腹痛。遂停用甲巯咪唑,并予"重组人粒细胞集落刺激因子、鲨肝醇、地榆升白片"升高白细胞,同时加强抗感染等对症治疗措施,2周后白细胞及中性粒细胞逐渐升至正常范围,病情稳定。
出处 《中国处方药》 2013年第1期49-50,共2页 Journal of China Prescription Drug
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