摘要
目的探讨COPD患者血清hs-CRP、TNF-α和IL-6的检测及其与肺功能和生活质量的相关性。方法选择120例COPD患者为观察组研究对象,选取同期体检的80例健康者为对照组。采用国内COPD生活质量评分表评估生活质量,比较两组血清hs-CRP、TNF-α和IL-6的差别,并对三者与COPD患者肺功能及生活质量的相关性进行探讨。结果观察组血清hs-CRP、TNF-α和IL-6水平显著高于对照组(P<0.05);在COPDⅡ级、Ⅲ级和Ⅳ级患者中,血清hs-CRP、TNF-α和IL-6水平逐渐升高(P<0.05),肺功能FEV1%、FEV1/FVC%逐渐降低(P<0.05),COPD生活质量评分逐渐减少(P<0.05);血清hs-CRP、TNF-α和IL-6水平与患者肺功能、生活质量呈负相关(P<0.05)。结论 COPD患者血清hs-CRP、TNF-α和IL-6水平异常升高,且与肺功能及生活质量显著相关。
[ Abstract] in COPD patients. Methods 120 COPD patients were selected as the experience group, and 80 healthy people were taken as the control group. Life quality of COPD patients was evaluated by domestic scale of life quality. The differences of hs-CRP, TNF-α and IL-6 between the two groups were compared, and their relationships to lung function and life quality were explored. Results The levels of serum hs- CRP, TNF-α and IL-6 were greatly higher in the experience group than in the control group （ P 〈 O. 05 ）. With the increase of COPD grade, the levels of serum hs-CRP, TNF-α and IL-6 increased gradually, and the lung function of FEV1% and FEVI/FVC% decreased gradually, as well as the scores of life quality （ P 〈 0.05 ）. The levels of serum hs-CRP, TNF-α and IL-6 were negatively correlated with lung function and life quality. Conclusion The levels of serum hs-CRP, TNF-α and IL-6 are abnormally high in COPD patients and neg- atively correlated with lung function and life quality.
出处
《临床肺科杂志》
2013年第4期616-617,共2页
Journal of Clinical Pulmonary Medicine
关键词
慢性阻塞性肺疾病
炎症因子
肺功能
生活质量
chronic obstructive pulmonary disease
inflammatory factor
lung function
life quality
