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炎症反应中P2X7受体影响NALP3炎症体形成的主要机制 被引量：2

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摘要 NOD样受体属于胞浆内受体,与Toll样受体一样广泛参与对病原体的识别,产生相应的免疫应答反应,炎症体作为NOD样受体家族重要成分,在宿主防御中是一个重要的传感器,与感染性疾病密切相关。机体免疫细胞膜表面的P2X7受体能被感染或损伤组织所释放的危险信号ATP作用而激活,细胞膜表面活化的P2X7受体能通过多种途径促进炎症体的产生,从而加重机体的炎症反应。本文将介绍炎症体的结构、P2X7受体在炎症反应中对其作用的主要机制及相应反应。
作者 神谢静 韩莉
机构地区 三峡大学医学院免疫学重点学科
出处 《现代免疫学》 CAS CSCD 北大核心 2013年第2期174-176,F0003,共4页 Current Immunology
基金 湖北省自然科学基金资助项目(2009CDZ024)
关键词 NOD样受体 P2X7受体 炎症体 炎症反应
分类号 R392 [医药卫生—免疫学]
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参考文献25

  • 1Diez-Zaera M, Diaz-Herndndez JI, Herndndez-alvarez E, et al. Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons[J]. Mol Biol Cell, 2011,22 1014-1024,.
  • 2Guerrero-Alba R, Valdez-Morales E, Judrez EH, etal. Two axramin binding sites are present in guinea pig hut only one in murine native P2X myenterie receptors[J], gut J Pharmaeol, 2010,626:179-185.
  • 3Gutirrez-Martin Y, Bustillo D, G6mez-Villafuertes R, etal. P2X7 receptors trigger ATP exocytosis and modify secretory vesicle dynamics in neuroblastoma cells[J]. J Biol Chem, 2011,286:11370 11381.
  • 4Costa-Junior HM, Marques-da-Silva C, Vieira FS, et al. Lipid metabolism modulation by the P2X7 receptor in the im- mune system and during the course of infection new insights into the old view[J]. Purinergic Signal, 2011,7 ： 381-392.
  • 5Beynon V, Quintana FJ, Weiner HL. Activated human CD4+ CD45RO + memory T-cells indirectly inhibit NLRP3 in{lammasome activation through downregulation o{ P2X7R Signalling[J]. PLoS One, 2012,7 e39576.
  • 6Stevenson RO, Taylor RM, Wiley .IS, etal. The P2X(7) re- ceptor mediates the uptake of organic cations in canine eryth- rocytes and mononuclear leukocytes comparison to equiva- lent human cell types [J]. Purinergic Signal, 2009,55 385- 394.
  • 7Ward JR, West PW, Ariaans MP, et al. Temporal interleu- kin-lbeta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mecha- nisms[J]. J Biol Chem, 2010,28523147-23158.
  • 8Netea MG, Nold-Petry CA, Nold MF, et al. Differential re- quirement for the activation of the inflammasome for process- ing and release of L-lbeta in monocytes and macrophages[J]. Blood, 2009,113 : 2324-2335.
  • 9Kumar H, Kawai T, Akira S. Pathogen recognition by th innate immune system [J]. Int Rev Immunol, 2011,30: 16- 34.
  • 10Kersse K, Bertrand MJ, Lamkanfi M, et al. NOD-like re- ceptors and the innate immune system: coping with danger, damage and death[J]. Cytokine Growth Factor Rev, 2011, 22:257-276.

二级参考文献34

  • 1Janeway CA Jr, Medzhitov R. Innate immune recognition[J]. Annu Rev Immunol, 2002,20:197-216.
  • 2Chen G, Shaw MH, Kim YG, et al. NOD-like receptors: role in innate immunity and inflammatory disease[J]. Annu Rev Pathol, 2009, 4:365-398.
  • 3Martinon F, Burns K, Tschopp J. The inflammasome: a mo- lecular platform triggering activation of inflammatory caspases and processing of pro-IL-beta[J]. Mol Cell,2002, 10:417- 426.
  • 4Martinon F, Mayor A, Tschopp J. The inflammasomes: guardiansof the body[J]. Annu Revlmmunol, 2009,27:229-265.
  • 5Kobayashi K, Inohara N, Hernandez LD, et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems[J]. Nature, 2002, 416:194-199.
  • 6Boyden ED, Dietrich WF. Nalplb controls mouse macrophage susceptibility to anthrax lethal toxin[J]. Nat Genet, 2006, 38: 240-244.
  • 7Franchi L, Amer A, Body-Malapel M, et al. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin lbeta in salmonella-infected maerophages[J]. Nat Immunol, 2006, 7:576-582.
  • 8Roberts TL, Idris A, Dunn JA, et al. HIN 200 proteins regulate easpase activation in response to foreign cytoplasmic DNA[J]. Science, 2009, 323:1057-1060.
  • 9Gross O, Poeck H, Bscheider M, etal. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host de fence[J]. Nature ,2009,459:433-436.
  • 10Muruve DA, Petrilli V, Zaiss AK, et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response[J]. Nature, 2008, 452: 103-107.

共引文献26

同被引文献14

  • 1李玮,朱佩芳,周元国.腺苷A2a受体的矛盾作用:保护还是加重损伤?[J].生理科学进展,2006,37(3):225-228. 被引量：8
  • 2赵士兵,何先弟.脓毒症晚期炎症介质HMGB-1[J].实用全科医学,2007,5(12):1099-1100. 被引量：2
  • 3中华人民共和国卫生部卫生监督司.保健食品检验与评价技术规范[M].北京:人民卫生出版社,2003:35-37.
  • 4Wu Z, Kong X,Zhang T, et al. Pseudoephedrine/ephedrine shows potent anti-inflammatory activity againstTNF-a-mediated acute liver failure induced by lippolysaccharide/d-galactosamine [J]. Eur J Pharmacol,2014, 724:112-121.
  • 5Zhu X C, Shiba H, Fung J J, et al. The Role of theA2a Receptor Agonist, Regadenoson, in ModulatingHepatic Artery Flow in the Porcine Small-for-Size LiverGraft [J]. J Surgical Res, 2012,174(1) :3745.
  • 6Che J, Chan E S, Cronstein B N. Adenosine A2Areceptor occupancy stimulates collagen expression byhepatic stellate cells via pathways involving proteinkinase A,Src, and extracellular signal-regulated kinases1/2 signaling cascade or p38 mitogen-activated proteinkinase signaling pathway [J]. Moi Pharmacol, 2007 , 72(6) :1626-1636.
  • 7Chiang D J, Roychowdhury S,Bush K,et al.Adenosine 2A receptor antagonist prevented and reversedliver fibrosis in a mouse model of ethanol-exacerbatedliver fibrosis[ J]. PLoS One,2013 , 8(7) :e69114.
  • 8Skaper S D, Debetto P, Uiusti P. The P2 X7 purinergicreceptor:from physiology to neurological disorders [J].
  • 9戴双双,周元国.腺苷A2A受体:机体免疫调节的重要分子[J].创伤外科杂志,2009,11(5):475-477. 被引量：2
  • 10刘双梅,梁尚栋.P2嘌呤受体与免疫和炎症[J].细胞与分子免疫学杂志,2009,25(12):1212-1213. 被引量：2

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现代免疫学
2013年 第2期

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