摘要
目的:系统评价复方甘草酸苷对酒精性肝病(ALD)患者肝功能的影响。方法:计算机检索Pubmed、中国期刊全文数据库和万方数据库,收集复方甘草酸苷治疗ALD的随机对照试验(RCT),同时辅以手工检索,评价纳入研究质量,合并结果进行Me-ta分析。结果:共纳入12项RCT,合计838例患者。Meta分析结果显示,试验组治疗后丙氨酸氨基转移酶[MD=-42.70,95%CI(-52.71,-32.69),P<0.01]、天冬氨酸氨基转移酶[MD=-47.93,95%C(I-62.77,-33.09),P<0.01]和γ-谷氨酰转肽酶[MD=-92.32,95%C(I-99.05,-85.60),P<0.01]水平均显著低于对照组。结论:复方甘草酸苷能够显著改善ALD患者肝功能。
OBJECTIVE： To evaluate the effects of Compound glycyrrhizin on liver function in patients with alcoholic liver disease. METHODS： Retrieved from Pubmed, CNKI and Wanfang database, randomized controlled trials （RCTs） about Compound glycyrrhizin in the treatment of alcoholic liver disease were collected, supplementing literature recourse retrieval. Quality evaluation and Meta-analysis of included literatures were conducted. RESULTS： A total of 12 RCTs were included, involving 838 cases. Meta-analysis results showed that the levels of alanine aminotransferase [MD=- 42.70,95 % CI （ -- 52.71, -- 32.69）, P〈 0.01] and aspartate aminotransferase [MD=--47.93,95%CI（--62.77,--33.09）, P〈0.01] and y-glutamyl transpeptidase [MD=--92.32,95%CI （ --99.05,- 85.60）, P〈0.01] in experimental group was lower than control group after treatment. CONCLUSION： Compound glycyrrhizin can significantly improve liver function in alcoholic liver disease.
出处
《中国药房》
CAS
CSCD
2013年第12期1116-1118,共3页
China Pharmacy
关键词
复方甘草酸苷
酒精性肝病
肝功能
META分析
Compound glycyrrhizin
Alcoholic liver disease
Liver function
Meta-analysis
