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尿微量蛋白检测早期评估缺氧缺血性脑病肾损伤的临床意义 被引量：2

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摘要 目的探讨尿微量蛋白水平在新生儿缺氧缺血性脑病(HIE)合并肾脏损伤早期评价中的应用价值。方法选择我科2010—2011年住院的足月HIE患儿为HIE组,同期选择产科分娩的健康足月新生儿为对照组,均在生后3天内检测尿β2微球蛋白(β2-M)、尿微量白蛋白(MA)、血清尿素氮(BUN)及肌酐(SCr)水平,并进行比较。结果 HIE组(76例)出生后3天内尿β2-M和MA均明显高于对照组(62例)[β2-M:(5.7±1.7)mg/L比(1.4±0.5)mg/L,MA:(32.5±21.5)mg/L比(7.9±2.9)mg/L,P<0.05];尿β2-M、MA的异常检出率均高于BUN、SCr[82.9%、89.5%比4.0%、9.2%,P<0.05]。结论窒息患儿出生后3天内检测尿β2-M和MA可作为早期判断HIE合并肾脏功能损伤的敏感指标。
作者 姜洁 田军新
机构地区 甘肃白银市第二人民医院儿科
出处 《中国新生儿科杂志》 CAS 2013年第2期111-112,共2页 Chinese Journal of Neonatology
关键词 缺氧缺性 脑 肾功能损伤 尿Β2微球蛋白 尿微量白蛋白
分类号 R722.1 [医药卫生—儿科]
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参考文献6

二级参考文献44

  • 1韩玉昆.新生儿缺氧缺血性脑病诊断依据和临床分度[J].中华儿科杂志,1997,35(2):99-100. 被引量：2786
  • 2Laterza OF,Price CP,Scott MG.Cystatin C:an improved estimator of glomerular filtration rate?Clin Chem,2002,48(5):699-707.
  • 3Gokkusu CA,Ozden TH,Gul H,et al.Relationship between plasma Cystatin C and creatinine in chronic renal diseases and Tx-transplant patients.Clin Biochem,2004,37(2):94-97.
  • 4Fliser D,Ritz E.Serum cystatin C concentration as a marker of renal dysfunction in the elderly.Am J Kidney Dis,2001,37(1):79-83.
  • 5Herget-Rosenthal S,Trabold S,Huesing J,et al.Cystatin C-an accurate marker of glome rular filtration rate after renal transplantation?Transplant Int,2000,13(4):285-289.
  • 6Martini S,Prevot A,Mosig D,et al.Glomerular filtration rate:measure creatinine and height rather than cystatin C!Acta Paediatr,2003,92(9):1052-1057.
  • 7Filler G,Priem F,Lepage N,et al.Beta trace protein,cystatin C,beta(2)-microglobulin,and creatinine compared for detecting impaired glomerular filtration rates in children.Clin Chem,2002,48(5):729-736.
  • 8Stabuc B,Vrhovec L,Stabuc-Silin M,et al.Improved prediction of decreased creatinine clearance by serum cystatin C:use in cancer patients before and during chemotherapy.Clin Chem,2000,46(2):193-197.
  • 9Jovanovic D,Krstivojevic P,Obradovic I,et al.Cystatin C as a measure of glomerular filtration in patients with kidney transplants.Srp Arh Celok Lek,2003,131(5-6):211-214.
  • 10Christensson A,Ekberg J,Grubb A,et al.Serum cystatin C is a more sensitive and more accurate marker of glomerular filtration rate than enzymatic measurements of creatinine in renal transplantation.Nephron Physiol,2003,94(2):p19-p27.

共引文献846

同被引文献33

  • 1杜逸亭,王译,李丽,罗德幸,郑毅.窒息新生儿尿系列微量蛋白与肾血流动力学改变的研究[J].四川医学,2012,33(11):1922-1925. 被引量：2
  • 2中华医学会儿科学分会新生儿学组.新生儿缺氧缺血性脑病诊断标准[J].中华儿科杂志,2005,43(8):584-584. 被引量：1302
  • 3Cavalleri F,Lugli L,Pugliese M,et al.Prognostic value of diffusion-weighted imaging summation scores or apparent diffusion coefficient maps in newborns with hypoxic-ischemic encephalopathy.Pediatr Radiol,2014,44:1141-1154.
  • 4Natarajan G,Pappas A,Shankaran S,et al.Effect of inborn vs.outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy:secondary analyses of the NICHD whole-body cooling trial.Pediatr Res,2012,72:414-419.
  • 5Aly H,Khashaba MT,El-Ayouty M,et al.IL-1beta,IL-6 and TNF-alpha and outcomes of neonatal hypoxic ischemic encephalopathy.Brain Dev,2006,28:178-182.
  • 6Luo M,Li Q,Dong W,et al.Evaluation of mild hypothermia therapy for neonatal hypoxic-ischaemic encephalopathy on brain energy metabolism using 18F-fluorodeoxyglucose positron emission computed tomography.Exp Ther Med,2014,8:1219-1224.
  • 7Matsui T,Kawahara N,Kimoto A,et al.Hypothermia Reduces but Hyperthermia Augments T Cell-Derived Release of Interleukin-17 and Granzyme B that Mediate Neuronal Cell Death.Neurocrit Care,2014,10:1-12.
  • 8Copin JC,Bengualid DJ,Da Silva RF,et al.Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathyway after transient focal cerebral ischemia in mouse.Eur J Neurosci,2011,34:1085-1092.
  • 9Lee JK,Kwak HJ,Piao Ms,et al.Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats.Acta Neurochir(Wien),2011,153:1321-1329.
  • 10Bednarek N,Svedin P,Garnotel R,et al.Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia-ischemia:a potential marker of neonatal encephalopathy.Pediatr Res,2012,71:63-70.

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中国新生儿科杂志
2013年 第2期

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