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神经莱姆病的研究进展 被引量：4

Advances in the study of Lyme neuroborreliosis
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摘要 莱姆病是20世纪70年代发现的以硬蜱作为传播媒介,由伯氏疏螺旋体感染所致的人兽共患传染病。国内于1986年在黑龙江省首次报道。其临床分为多个阶段,可造成多个器官损害,其中神经系统的损害是莱姆病的主要表现之一,临床表现多样无特异性,已引起医学界的高度重视。本文对近年神经莱姆病的研究进展作一综述。 Lyme disease is a zoonotic, vector-borne infection that first appeared in the 1970s. The disease is transrnit- ted by the tick borne spirochete Borrelia burgdorferi. In China, Lyme disease was reported for the first time in Hei longjiang Province in 1986. Clinically, it can be divided into multiple stages and causes multi-system damage. Damage to the nervous system is one of the major manifestations of Lyme disease. Its clinical manifestations are varied and nonspecif ic, so it has garnered the attention of the medical field. This paper mainly reviews recent advances in the study of Lyme neuroborreliosis.
作者 李静 宝福凯 柳爱华
机构地区 昆明医科大学热带医学研究所 昆明医科大学生物化学与分子生物学系
出处 《中国病原生物学杂志》 CSCD 北大核心 2013年第2期178-180,共3页 Journal of Pathogen Biology
基金 国家自然科学基金项目(No.81060134) 云南省自然科学基金项目(No.2007C069M,2010CD221,2011FB244)
关键词 莱姆病 伯氏疏螺旋体 神经莱姆病 发病机理 抗生素 综述 Lyme disease Borrelia burgdorferi Lyme neuroborreliosis pathogenesis antibiotic review
分类号 R514 [医药卫生—内科学]
  • 相关文献

参考文献33

  • 1Aguero-Rosenfeld ME, Wang G, Schwartz I, et al. Diagnosis of Lyme disease [J], Clin Mierobiol Rev,2005,18(2) :484-509.
  • 2宝福凯,柳爱华,马海滨,吴娜.莱姆关节炎发病机理研究进展[J].中国病原生物学杂志,2009,4(5):380-382. 被引量：15
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二级参考文献43

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共引文献33

同被引文献29

  • 1于东冬,王峰,牛俊奇,王春生,马敬民.吉林省莱姆病伯氏疏螺旋体外膜蛋白A的初步研究[J].中华传染病杂志,2006,24(1):17-19. 被引量：2
  • 2Steere AC. Lyme disease[J]. N Engl J Med, 2001; 345:115-125.
  • 3Steere AC, Cobum J, and G|ickstein L. The emergence of Lyme disease[J]. J Clin Invest, 2004; 113: 1093- 1101.
  • 4Feder HM Jr, Johnson BJB, Connell SO, et al. A critical appraisal of "cronic Lyme disease" [J]. N Engl J Med, 2007; 357:1422-1430.
  • 5Wormser GP. Early Lyme disease[J]. N Engl J Med, 2006; 354:2794- 2801.
  • 6Steere AC. Lyme borreliosis in 2005, 30 years after initial observations in Lyme Connecticut[J]. Wien Kiln Woehenschr, 2006,118:625-633.
  • 7Roberts ED, Bohm RP, Lowrie RC, et al. Pathogenesis of lyme neuroborreliosis in the rhesus monkey: the disseminated and chronic phases of disease in the peripheral nervous system[J]. J Infeet Dis, 1998, 178(3): 722-732.
  • 8Rupprecht TA, Kirschning C J, Popp B, et al. Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2 [J]. Infection and immunity, 2007, 75(9): 4351-4356.
  • 9Rupprecht TA, Plate A, Adam M, et al. The chemokine CXCLI3 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis[J]. J Neuroinflammation, 2009, 6(42): 1-11.
  • 10Bremell D, Mattsson N, Edsbagge M, et al. Cerebrospinal fluid CXCL13 in Lyme neuroborreliosis and asymptomatic HIV infection [J]. BMC neurology, 2013, 13(1): 2.

引证文献4

二级引证文献5

中国病原生物学杂志
2013年 第2期

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