摘要
目的:探讨氯胺酮对兔全脑缺血再灌注损伤血流动力学的影响。方法:新西兰大耳白兔15只,随机分为对照组(A组)、模型组(B组)、氯胺酮组(C组),B、C组采用两血管结扎加股动脉放血法制备全脑缺血模型,C组于夹毕双侧颈总动脉后经股静脉匀速静注氯胺酮,术中监测脑电图(EEG)、心电图(ECG)、平均动脉压(MAP)、心率(HR)。结果:B、C组HR在缺血30 min均较A组显著增快(P<0.01);B组动物在再灌注30 min HR明显低于A组(P<0.01),B组MAP在缺血30 min均较A、C组显著降低(P<0.01),恢复再灌注30 min后增高,但仍低于基础值(P<0.01);C组EEG在缺血30 min及再灌注30 min后均较A、B组显著增高(P<0.01)。C组缺血30 min内HR显著高于B组(P<0.01),而C组再灌注30 min HR明显高于B组(P<0.01)。结论:氯胺酮能较好地维持兔全脑缺血再灌注期间血流动力学稳定,可有效减轻全脑缺血再灌注导致的脑损伤。
Objective： To investigate the effects of ketamine on haemodynamics in global cerebral ischemia reperfusion injury of rabbits. Methods ： Fifteen adult healthy New Zealand white rabbits were randomly divided into control group （ group A）, model group （group B） and ketamine group （group C ）. The global cerebral ischemia reperfusion model of group B and C was established by two- vessel occlusion combined with femoral arterial bloodletting. The rabbits in group C were injected with ketamine by femoral vein after nipping bilateral common carotid arteries, and electroencephalogram （ EEG）, electrocardiogram （ ECG）, mean arterial blood pressure （MAP） and heart rate（HR） were monitored during operation. Results： Compared with group A, the HR of group B and C sped significantly up at 30 minutes after ischemia （P 〈 0.01 ）, and the HR of group B was significantly lower than that in group A （P 〈 0.01 ） at 30 min after reperfusion. The MAP of group B were significantly lower than that in group A and C （ P 〈 0.01 ） at 30 min after ischemia,and began to rise at 30 mins after reperfusion and was still less than basic value（P 〈 0.01 ）. The EEG of group C was significantly higher than that in group A and B at 30 mins after ischemia and reperfusion （ P 〈 0. O1 ）. The HR of group C was significantly higher than that in group B at 30 min after ischemia（ P 〈 0.01 ）, and HR at 30 mins after reperfusion of group C were significantly higher than that in group B （P 〈 0.01 ）. Conclusions： Ketamine can maintain the haemodynamic stability of rabbit global cerebral ischemia reperfusion injury ,which can effectively alleviate and reduce brain injury caused by ischemia reperfusion.
出处
《蚌埠医学院学报》
CAS
2013年第2期129-130,133,共3页
Journal of Bengbu Medical College
基金
蚌埠医学院科研基金资助项目(BY1055)
关键词
脑损伤
氯胺酮
血流动力学
兔
cerebral injury
ketamine
haemodynamic
rabbit
