摘要
目的 探讨凝血因子Ⅶ (FⅦ )在心肌梗死 (MI)发病中的作用 ,为MI的防治提供依据。方法 测定 31例健康者和 33例陈旧性心肌梗死 (OMI)患者血浆FⅦ促凝活性 (FⅦC) ,并观察 2 2例MI患者急性期 (AMI)的动态变化。结果 ①OMI患者血浆FⅦC(12 0 0± 15 3) %显著高于健康者(10 6 0± 12 3) % ,P <0 0 1;②AMI患者血浆FⅦC 于发病 12h内 (10 3 5± 16 3) %和 3天时 (10 6 5±11 0 ) %与健康者差异无显著性 (P >0 0 5 ) ,其后逐渐升高 ,至 3周时 (12 4 7± 16 9) %与OMI患者水平相近 (P >0 0 5 )。③血浆FⅦC 与血清甘油三酯呈显著正相关 (r =0 78,P <0 0 1)。结论 心肌梗死患者存在FⅦ的慢性激活和高凝状态 ;AMI病程初期伴有FⅦ的短暂激活和大量消耗。
Objective To elucidate the role of coagulation factor Ⅶ (FⅦ) in the pathogenesis of myocardial infarction (MI) in Chinese. Methods Plasma FⅦ coagulation activity (FⅦ C) was measured in 31 healthy individuals and 33 post-MI patients by one-stage prothrombin time method. The changes of plasma FⅦ C during acute phase of 22 MI cases (AMI) were also assessed. Results Post-MI patients had significantly higher plasma FⅦ C as compared with healthy subjects [(120 0±15 3)% vs (106 0±12 3)%, P <0 01]. Patients with AMI had rather low levels of FⅦ C within 12 hours of (103 5±16 3)% and 3 days after (106 5±11 0)% the symptom onset, which were not significantly different from those of healthy individuals ( P> 0 05). After that, FⅦ C became increasingly higher, being (113 0±11 4)% in one week and reaching its peak (124 7±16 9)% on 21st day after onset, which was comparable to those of post-MI group ( P >0 05). A significantly positive correlation was found between serum triglyceride and plasma FⅦ C ( r =0 78, P <0 01). Conclusion Chronic activation of FⅦ and a hypercoagulant state exist in MI patients. Significant consumption following transient activation of FⅦ occurs during acute phase of AMI.
出处
《中华心血管病杂志》
CSCD
北大核心
2000年第4期277-278,共2页
Chinese Journal of Cardiology
