基础胰岛素的临床效果及药物经济学评价综述被引量：3

Clinical eff icacy and pharmacoeconomic evahiation of basal insalin

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摘要采用文献综述法,系统地分析国内外已发表的地特胰岛素(IDet)、甘精胰岛素(IGlar)和中性鱼精蛋白胰岛素(NPH)的临床研究和经济学评价结果,以评价地特胰岛素、甘精胰岛素和中性鱼精蛋白胰岛素治疗1型和2型糖尿病患者(T1DM/T2DM)的临床疗效和经济学价值。研究结果表明,在临床效果方面,患者从应用口服降糖药转换成口服药合并中性鱼精蛋白锌胰岛素(NPH)、甘精胰岛素注射液(IGlar)或地特胰岛素注射液(IDet)后,均有助于进一步降低患者的血糖水平,减少体重增加、夜间低血糖等不良反应的发生。许多国家的经济学研究显示,与NPH相比,IGlar是具有成本-效果的治疗方案;与NPH或IGlar相比,IDet是成本节约或具有成本-效果的治疗方案。

作者牟岚马敬东

机构地区华中科技大学同济医学院医药信息管理系

出处《药品评价》 CAS 2013年第3期16-21,共6页 Drug Evaluation

关键词糖尿病基础胰岛素地特胰岛素甘精胰岛素中性鱼精蛋白锌胰岛素成本-效果分析

分类号 R587.1 [医药卫生—内分泌]

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参考文献31

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