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25(OH)D与2型糖尿病视网膜病变程度的相关性 被引量：11

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摘要 目的探讨25-羟基维生素D[25(OH)D]与2型糖尿病视网膜病变严重程度的相关性。方法选择200例2型糖尿病患者(病例组),按眼底造影分期分为无糖尿病视网膜病变组、背景型视网膜病变组、早期增殖期视网膜病变组及增殖期视网膜病变组各50例。另选50例非糖尿病患者作为对照组。分别检测各组血清25(OH)D、糖化血红蛋白、血脂及肝肾功能。结果血清25(OH)D水平随着糖尿病视网膜病变的严重程度逐渐降低(P均<0.05),且均明显低于对照组(P均<0.05)。多元逐步回归分析示,血清25(OH)D受糖尿病视网膜病变程度分级、病程及糖化血红蛋白影响较大(P均<0.05)。结论 25(OH)D缺乏在糖尿病视网膜病变中广泛存在,且随着糖尿病视网膜病变眼底分级程度呈下降趋势,可作为预测糖尿病视网膜病变严重程度的指标之一。
作者 韩改玲 鲁娜 王翠娟 刘晓丽 王蕊 马宁 王锐 秦春梅 陆强
机构地区 秦皇岛市第一医院
出处 《山东医药》 CAS 2013年第10期34-35,共2页 Shandong Medical Journal
关键词 糖尿病视网膜病变 25-羟基维生素D 荧光素血管造影术
分类号 R587.2 [医药卫生—内分泌]
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参考文献8

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同被引文献91

  • 1贾丽丽,吴强,尹茶仙,陆斌,戴友林,杨冠,包玉倩.Ⅱ型糖尿病患者糖尿病视网膜病变患病率的调查分析[J].中国眼耳鼻喉科杂志,2006,6(4):226-228. 被引量：9
  • 2Malecki MT, Osmenda G, Walus-Miarka M, et al. Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction[J]. Eur J Clin Invest, 2008,38(12) :925-930.
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  • 5Nagaoka T, Sato E, Takahashi A, et al. Impaired retinal circula- tion in patients with type 2 diabetes mellitus: retinal laser Doppler velocimetry study[ J ]. Invest Ophthalmol V is Sci, 2010,51 (12) : 6729-6734.
  • 6Li J, Wang JJ, Yu Q, et al. Endoplasmic reticulum stress is impli- cated in retinal inflammation and diabetic retinopathy [J]. FEBS Lett, 2009,583 (9) : 1521-1527.
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  • 8Wang CH, Li SH, Weisel RD, et al. C-reactive protein upregu- lates angiotensin type I receptors in vascular smooth muscle[J]. Circulation, 2003,107 ( 13 ) : 1783-1790.
  • 9Sogawa K, Nagaoka T, Tanano I, et al. Association between dia- betic retinopathy and flow-mediated vasodilation in type 2 DM[ J]. Curt Eye Res, 2012,37 (5) :446-451.
  • 10Aksoy H,Ak(C)ay F,Kurtul N,et al.Serum 1,25 dihydroxy vitamin D (1,25(OH)2D3),25 hydroxy vitamin D (25(OH)D) and parathormone levels in diabetic retinopathy.Clin Biochem,2000,33(1):47-51.

引证文献11

二级引证文献59

山东医药
2013年 第10期

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