摘要
目的分析心脏死亡器官捐献(DCD)供肾移植后早期肾功能恢复情况。方法通过Pubmed/Medline、Embase和Cochrane等数据库检索1950年至2011年正式发表的DCD肾移植和脑死亡器官捐献(DBD)肾移植早期肾功能恢复情况的相关单中心的文献,进行荟萃分析。对移植物功能延迟恢复(DGF)和原发性肾脏无功能(PNF)的发生情况进行分析,计算比值比(OR)和95%可信区间(CI)。结果最终纳入9篇文献,包括DCD肾移植2049例和DBD肾移植5498例。DCD肾移植后DGF发生率为37.5%,DCD肾移植后DGF发生的OR为7.24(95%CI为3.86~13.58);DCD肾移植后PNF发生率为18.20,DCD。肾移植后PNF发生的OR为4.97(95%CI为3.77~6.55)。DCD肾移植和DBD肾移植受者1、3、5和10年存活率的差异均无统计学意义,移植肾1、3、5和10年存活率的差异也均无统计学意义。结论DCD肾移植后的DGF和PNF发生率较高,从而影响早期肾功能恢复。
Objective To compare the early renal function recovery after kidney transplant from donation after cardiac death (DCD) and brain death (DBD). Methods The Medline (1950-2011), Embase and Cochrane library database were searched and supplemented by review of conference proceedings and publication bibliographies. All original single institution studies reporting outcomes for DCD and DBD kidney transplant recipients were considered. Odds ratios (OR) and 95% confidence intervals (CI) based on random effects models were calculated. Results Nine publications, all cohort studies, involving 2049 DCD and 5498 DBD recipients, were included. DCD recipients had 7. 24 times increased odds of DGF (OR= 7. 24, 95% CI = 3.86 - 13.58), and 4. 97 times increased odds of PNF (95% CI = 3. 77 - 6. 55). Conclusion DCD renal transplantation is associated with higher risks of DGF and PNF.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2013年第3期167-170,共4页
Chinese Journal of Organ Transplantation
基金
基金项目:卫生部行业专项基金(201002004)
教育部科学技术研究重点项目(2010048)
教育部高等学校博士学科专项科研基金(20092104110006)
关键词
肾移植
心脏死亡捐献
脑死亡捐献
meta分析
Kidney transplantation
Donation after cardiac death
Donation after brain death
Meta analysis