摘要
目的 :评价静息心肌收缩功能与血流储备的关系。 方法 :以安放“水膨胀”式缩窄器的方法建立 11只慢性多支冠状动脉 (冠脉 )狭窄闭胸犬。术后 7～ 10天在静息状态下以二维超声心动图测定室壁增厚百分率 (% WT) ,同时以放射性微球测定心肌血流量 (MBF)和 MBF储备。 结果 :在 40个心室壁运动异常的心肌节段与 42个心室壁收缩功能正常的心肌节段之间 ,静息心室壁和心内膜下血流均无明显差异 ,但后者的心室壁和心内膜下血流储备均明显低于前者。静息状态 % WT与 MBF储备密切相关 (P<0 .0 0 1)。 结论 :在静息状态血流无限制的慢性冠脉狭窄犬 ,% WT异常心肌节段的 MBF储备明显降低 ,静息状态 % WT与MBF储备密切相关 ,表明局部收缩功能异常可能是由于反复“需氧增多”性心肌缺血所致。
Objectives:To evaluate the relationship between the wall thickening percentage (%WT) and myocardial blood flow (MBF) reserve when resting MBF is normal in chronic coronary stenosis. Methods:Twelve closed chest dogs were studied at 7 10 days after placement of Ameroid constrictors around proximal portions of the coronary arteries.%WT was measured with 2D echocardiography at rest,meanwhile MBF and MBF reserve (induced by dipyridamole) were measured with radiolabeled microspheres. Results:Regional wall motion abnormality (RWMA,%WT<30%) was present in 40 of 82 segments at rest.There was no significant difference between RWMA and no RWMA in resting transmural and endocardial MBF (p>0 05).Both transmural and endocardial MBF reserve,were reduced (p<0 01) in segments with a resting RWMA,compared to those with no RWMA.A close relation was noted between %WT and transmural and endocardial reserve (p<0 001). Conclusions:In the setting of chronic coronary stenosis when resting MBF is normal,a RWMA is associated with MBF reserve decrease.The coupling between resting %WT and MBF reserve is close.These results indicate that repetitive myocardial ischemia may be responsible for abnormalities in resting %WT in CAD despite normal resting MBF.
出处
《中国循环杂志》
CSCD
北大核心
2000年第5期302-303,共2页
Chinese Circulation Journal
基金
美国卫生部基金部分资助!(R0 1- HL48890 )
国家自然基金部分资助!(39870 32 9)
关键词
心肌血流储备
冠状动脉狭窄
静息心肌收缩功能
Myocardil blood flow
Myocardial blood flow reserve
Myocardial contractile dysfunction
Coronary stenosis
