摘要
为研究ALAD基因多态性对铅致神经毒性的影响 ,对 179名生活在严重铅污染环境中的 6～ 8岁儿童进行基因型分析、血铅和锌原卟啉 ,身高、体重、血红蛋白、智商和反应时测定。结果表明 ,与ALAD1- 1纯合子相比 ,ALAD1- 2杂合子的血铅和锌原卟啉都轻度增高但没达到显著性水平。而两组的体格和智力发育参数都十分接近 ,但ALAD1- 2组的反应时延长 (P =0 0 2 )。在应用协方差分析充分均衡了两组的血铅水平后 ,ALAD1- 2的选择反应时间与ALAD1- 1组十分接近。结果提示ALAD1- 2基因型对铅致神经毒性效应与AL AD1- 1的效应存在差异 。
Associations between δ-aminolevulinic acid dehydratase(ALAD) polymorphism and lead-induced neurotoxicity were investigated among 179 children whom have been living in lead polluted environment. The authors examined associations of ALAD genotype with blood lead and zinc protoporphyrin(ZPP) levels,intelligence quotient(IQ), choice reaction time.Comparing with ALAD1 1 genotype,the ALAD1-2 genotype had slight increased blood lead and ZPP levels but there were not significantly differences. The subject with ALAD1-2 genotype had slowly reactive time in choice reaction test (P=0.02). No differences between genotypes were found for body weight, high, hemoglobin and IQ. When the blood lead level was adjusted by covariance analysis, reactive time in choice reaction test of the ALAD1-2 genotype was closed to that of ALAD1-1 homozygote. The results suggest that ALAD1-2 subjects respond differently to lead-induced neurotoxic effects, the mechanism maybe relate to gene-mediated increased lead load in body.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2000年第10期908-910,共3页
Chinese Journal of Public Health
基金
国家自然科学基金和九五攻关课题资助
