摘要
在单因素实验的基础上,采用Box-Behnken设计-效应面法(RSA)对影响茴香油β-CDP微球包合物的制备工艺的主要因素反应温度、β-CDP微球与茴香油投料比、水与β-CDP微球投料比进行了优化,并建立了相应的预测模型。经二次多项数学模型分析得到优化制备条件为:茴香油用量1mL、β-CDP微球用量5.7g、水用量50mL、包合温度40℃、包合时间1h,此条件下茴香油平均包合率为86.9%、微球包合物平均产率为93.9%。经验证,应用效应面法所得到的茴香油β-CDP微球包合物制备工艺是可行的。
On the basis of single factor experiment,a three-factor, three-level Box-Behnken design combining with response surface methodology （RSA） was employed to optimize three crucial preparation conditions for aniseed oil-β-cyclodextrin polymer microspheres inclusion compound. The mathematical regression model indi-cated that the optimum technological conditions were as follows： aniseed oil amount was 1 mL, water amount was 50 mL,β-CDP amount was 5.7 g,inclusion temperature was 40℃ and inclusion time was 1 h. The average encapsulation rate of aniseed oil, the average yield of the inclusion compound under the optimized conditions were 86.9% and 93.9%, respectively. It was verified that the optimum preparation process for aniseed oil-β- CDP microspheres inclusion compound was feasible.
出处
《化学与生物工程》
CAS
2013年第3期50-53,共4页
Chemistry & Bioengineering
基金
陕西省卫生厅科研资助项目(2012D14)
陕西省教育厅科研计划资助项目(11JK0694)
关键词
茴香油
β-CDP微球包合物
BOX-BEHNKEN设计
效应面法
aniseed oil
β-cyclodextrin polymer microspheres inclusion compound
Box-Behnken design
re-sponse surface methodology
