摘要
目的:对结直肠癌肝转移的临床特征进行分析,探讨影响结直肠癌肝转移的危险因素。方法:收集2007年11月至2010年6月武汉大学中南医院所收治的101例结直肠癌肝转移患者的临床病理特征,包括肿瘤大小、肿瘤组织学分级、淋巴结转移、术前血清肿瘤标志物水平等,并随机抽取2007年11月至2010年6月间无肝转移的结直肠癌患者81例作为对照组,进行Logistic多因素回归分析,研究与结直肠癌肝转移相关的危险因素。结果:血清CEA、CA125、CA19-9水平升高与肝转移危险增加相关(P<0.05)。Logistic多因素回归分析显示血清CEA、CA125、CA19-9水平是结直肠癌肝转移的独立相关因素(P<0.05)。结论:血清CEA、CA125、CA19-9水平是结直肠癌肝转移的危险因素。
Objective： To determine the risk factors affecting hepatic metastasis from colorectal cancer. Methods： The clinicopathologieal factors, such as gender, age, tumor size, histological grade, lymph node metastasis and serum level of tumor markers were analyzed in 101 cases of colorectal cancer with hepatic metastasis and 81 cases without hepatic metastasis. Results： The elevated ser- um levels of CEA, CA125, and CA19-9 were associated with hepatic metastasis. Logistic regres- sion analysis revealed that the independent risk factors of hepatic metastasis were the serum level of CEA, CA125, and CA19-9 （P〈0.05）. Conclusion： The serum levels of CEA, CA125, and CA19-9 were statistically significant risk factors for hepatic metastasis from colorectal cancer.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2013年第2期222-224,共3页
Medical Journal of Wuhan University
