摘要
目的:分析胃癌患者术前血清骨桥蛋白(OPN)浓度与术后转移复发及生存预后之间的关系,评价其在预测胃癌术后复发及生存中的作用。方法:对照组选取28例健康人体检血清标本;病例组选取手术切除的135例胃癌患者的术前血清标本,用酶联免疫吸附(ELISA)法检测血清OPN浓度。比较对照组与病例组血清OPN浓度;并随访病例组患者转移复发及生存情况,分析统计血清OPN浓度与胃癌患者临床病理参数以及复发生存预后的关系。结果:胃癌组血清OPN浓度为(111.70±9.26)μg/L,对照组血清OPN浓度为(36.27±4.90)μg/L,两组相比较存在显著性差异(P<0.01)。胃癌病例组中复发患者血清OPN浓度(161.35±20.94)μg/L较未复发组浓度(87.70±8.26)μg/L明显增高。回归分析显示血清OPN浓度与肿瘤大小(P<0.01)有关。高OPN浓度组的总生存(OS)时间(P<0.01)和至复发(TTR)时间(P<0.01)均明显低于低OPN浓度组。应用Cox风险回归模型分别进行单因素及多因素分析,结果显示术前血清OPN浓度是影响胃癌患者术后复发及生存的一个独立危险因素。结论:胃癌患者术前血清OPN浓度与术后复发和生存密切相关,可以成为预测胃癌转移复发及生存的分子指标。
Objective. To evaluate the value of osteopontin（OPN） detection in forecasting the postopera- tive recurrence and survival rate of gastric cancer. Methods. Serum OPN level of 135 patients with gastric cancer was detected before operation by enzyme-linked immunosorbent assay （ELISA）, and serum samples of 28 healthy volunteers were also analyzed as control group. The correlation of serum OPN level to metastasis and recurrence of gastric cancer was analyzed. Results. Serum OPN level was significantly higher in gastric cancer group than in control group as （111. 70±9.26） /xg/L vs （36.27±4.90）μg/L （P〈0.01）. Logistic regression showed that ser- um OPN level was significantly associated with tumor size （P〈0.01）. Serum OPN level was demonstrated significant associated with gastric cancer patient＇s recurrence and survival （P〈0. 01）. COX multivariate analysis showed that serum OPN level was an independent predictor for gastric cancer recurrence and survival. Conclusion. Serum OPN level may be a potential biomark- er for predicting postoperative recurrence and survival of gastric cancer patients.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2013年第2期280-284,共5页
Medical Journal of Wuhan University
关键词
胃癌
骨桥蛋白
复发
预后
Gastric Cancer
Osteopontin
Prognosis
Recurrence
