摘要
目的探讨不同浓度七氟烷对急性肺损伤大鼠的保护作用。方法选择12只雄性SD大鼠，随机分为两组各6只，A组吸人七氟醚浓度为0．5％-1．0％，B组则吸入七氟醚浓度在1．0％-2．5％之间，持续进行3h，之后处死大鼠，比较两组大鼠DAD各项目评分以及白细胞计数、肿瘤坏死因子-α（TNF-α）水平。结果A组h细胞计数显著低于B组（P〈0．05），TNF-α水平低于B组（P〈0．05），A组肺泡纤维素渗出、肺泡出血、肺间质水肿、肺泡和肺间质中性粒细胞聚集评分均显著低于B组（P〈0．05）。结论七氟烷对急性肺损伤大鼠肺组织炎症反应有一定的抑制作用，其中吸入七氟醚浓度0．5％-1．0％之间者具有更好的肺保护作用。
Objective To investigate the protective effect of different concentrations of sevoflnrane on acute lung injury with rats. Methods 12 male SD rats were randomly divided into two groups,each group with 6 rats,group A were inhaled sevoflurane concentration with 0.5%-1.0%,group B were inhaled sevoflurane concenlralion with 1.0%-2.5% after 3 h the rats were killed,then DAD each item score and white blood cell count,tumor necrosis factor-αt level were compared in the two groups. Results In A group,the white blood cell count was lower than B group （P 〈 0.05）, TNF- α levels was lower than B group （P 〈 0.05）,alveolar fibrin exudation,alveolar hemorrhage,pulmonary interstitial edema,alveolar and interstitial lung neutrophil aggregation score were lower than group B （P 〈 0.05）. Conclusion Sevoflurane on acute lung injury rats can inhibit inflammatory responses in lung tissue and inhaled sevoflurane concentration between 0.5%-1.0% has better protective effect.
出处
《中国医药科学》
2013年第6期24-25,28,共3页
China Medicine And Pharmacy
基金
河北省卫生厅科研基金项目(20120138)
关键词
急性肺损伤
不同浓度
七氟烷
大鼠
Acute lung injury
Different concentrations
Sevoflurane
Rats
