摘要
目的观察炔雌醇环丙孕酮片联合二甲双胍治疗肥胖型多囊卵巢综合征的疗效。方法 58例多囊卵巢综合症患者,从自然月经或撤退性出血的5 d开始,每晚口服炔雌醇醋酸环丙孕酮,21 d为1个周期;治疗结束,撤退性出血第5d开始,进行下一个周期,连服3个月,同时服用二甲双胍500 mg,2次/日。服药3个月后,检查体重指数、治疗前后的卵泡刺激素(FSH)、促黄体激素(LH)及睾酮(T)。结果治疗前后,体重指数分别为(27.50±2.86),(25.1±4.0)kg.m-2,T分别为(2.74±1.57),(1.46±0.80)mmol.L-1,LH/FSH比值分别为3.41±2.20,1.78±1.20,均明显下降(均P<0.05)。结论炔雌醇醋酸环丙孕酮联合二甲双胍有效改善临床症状、内分泌水平、降低胰岛素抵抗及体重指数。
Objective To investigate the effects of ethinylestradiol and cyproterone acetate tablets combined with metformin in the treatment of obese women with polycystic ovary syndrome（PCOS）.Methods Fifty-eight cases of obese women with PCOS were involved.From natural menstruation or retreat hemorrhages 5 d beginning,every night oral ethinylestradiol cyproterone acetate,21 d for a cycle.The end of treatment,retreat hemorrhages 5 d beginning,for the next cycle,at the same time was give metformin 500 mg,every time twice a day for 3 months.The body mass index（BMI）,follicle-stimulating hormone（FSH）,luteinizing hormone（LH）,testosterone（T） were examined before and after treatment.Results BMI were（27.50±2.86）,（25.1±4.0） kg·m-2;T were（2.74±1.57）,（1.46±0.80） mmol·L-1;LH/FSH ratio were（3.41±2.20）,（1.78±1.20） before and after treatment respectively.There were decreased significantly compared with before treatment（P0.05）.Conclusion Ethinylestradiol and cyproterone acetate tablets joint metformin effectively improve clinical symptoms and endocrine level,reduced the insulin resistance and BMI.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2013年第3期175-176,共2页
The Chinese Journal of Clinical Pharmacology
关键词
多囊卵巢综合症
炔雌醇醋酸环丙孕酮
二甲双胍
polycystic ovary syndrome
ethinylestradiol and cyproterone acetate tablets
metformin
