摘要
目的:观察经纤维支气管镜行盐酸氨溴索灌洗治疗支原体肺炎伴肺不张的疗效。方法:将87例支原体肺炎伴肺不张患儿随机分为常规治疗组(n=41)、盐酸氨溴索组(n=46)。2组在常规阿奇霉素治疗的情况下,常规治疗组经纤维支气管镜进行生理盐水灌洗肺不张处,而盐酸氨溴索组予以生理盐水稀释的盐酸氨溴索注射液灌洗。观察两组患儿发热时间及灌洗前后咳嗽次数,并于2周后复查胸部CT,比较两组疗效。结果:两组患儿经纤维支气管镜行灌洗治疗后咳嗽次数均较灌洗前明显减少(P<0.05),且灌洗后盐酸氨溴索组咳嗽次数为(18.07±4.78)次/d,明显少于常规治疗组灌洗后的(28.07±3.39)次/d(P<0.05)。盐酸氨溴索组患儿肺不张治疗的总有效率(97.83%)高于常规治疗组(92.68%)(P<0.05)。但常规治疗组与盐酸氨溴索组的发热时间分别为(5.12±1.22)d、(5.37±2.01)d,差异无显著意义(P>0.05)。结论:经纤维支气管镜行盐酸氨溴索灌洗治疗支原体肺炎伴肺不张是一种行之有效的临床手段。
OBJECTIVE： To observe the therapeutic efficacy of ambroxol hydrochloride irrigation in the treatment of mycoplas- mal pneumonia complicating with pulmonary atelectasis via bronchoscopy. METHODS： 87 mycoplasmal pneumonia （MPP） pa- tients with pulmonary atelectasis were randomized into conventional therapy group （n=41） and ambroxol hydrochloride group （n= 46）. On the basis of conventional therapy of azithromycin, normal saline （NS） were infused via bronchoscopy in conventional ther- apy group and irrigation of ambroxol hydrochloride diluted by NS was conducted in ambroxol hydrochloride group. The time of fe- ver and cough times were observed in 2 groups, and the CT were reviewed 2 weeks later. Therapeutic efficacies were compared be- tween 2 groups. RESULTS： The times of cough were decreased significantly in 2 groups after bronchoscopy lavage （P〈0.05）, （18.07 ± 4.78）times/d in ambroxol hydrochloride group which was significantly lower than （28.07 ± 3.39）times/d in conventional treatment group （P〈0.05）. Total effective rate of ambroxol hydrochloride group （97.83%） was higher than that of conventional treatment group （92.68%） （P〈0.05）. The time of fever was （5.12±1.22）d in conventional therapy group and（5.37 ± 2.01）d in am- broxol hydrochloride group, there was no statistical significance （P〉0.05）. CONCLUSIONS： Ambroxol hydrochloride irrigation via bronchoscopy is an effective method for treatment of mycoplasmal pneumonia complicating with pulmonary atelectasis.
出处
《中国药房》
CAS
CSCD
2013年第14期1299-1301,共3页
China Pharmacy
关键词
支原体肺炎
肺不张
纤维支气管镜灌洗
盐酸氨溴索
Mycoplasmal pneumonia
Pulmonary atelectasis
Bronchoalveolar lavage
Ambroxol hydrochloride
