摘要
大量研究已证实高尿酸血症（HUA）与2型糖尿病（T2DM）密切相关，HUA患者中T2DM发生率显著高于尿酸正常者，而T2DM患者相对于非糖尿病者更容易发展为HUA。HUA可能通过引起慢性炎性反应和胰岛素抵抗参与T2DM的发生、发展，而T2DM中HUA发生率高可能与氧化应激和高胰岛素血症有关。另外，HUA与糖尿病并发症之间也存在紧密联系。
Lots of studies have identified the relationship between hyperuricemia（HUA） and type 2 diabetes mellitus（T2DM）. The incidence of T2DM in patients with HUA is higher than that in individuals with normouricemia（NUA）. Compared with nondiabetic subjects,patients with T2DM are more likely to de- velop HUA. HUA may participate in the occurrence and development of T2DM by causing chronic inflamma- tory reaction and insulin resistance, while the high incidence of HUA in T2DM may related with oxidative stress and hyperinsulinemia. Also, HUA is significantly associated with diabetic complications.
出处
《国际内分泌代谢杂志》
北大核心
2013年第2期126-128,共3页
International Journal of Endocrinology and Metabolism
关键词
高尿酸血症
2型糖尿病
胰岛素抵抗
Hyperuricemia
Type 2 diabetes mellitus
Insulin resistance
