摘要
目的 :探讨非清除性异基因干细胞移植在难治性急性白血病治疗中的作用。方法 :3例难治性急性白血病 ,采用环胞霉素 A、环磷酰胺、阿糖胞苷或抗淋巴细胞球蛋白等作非清除性预处理的异基因外周造血干细胞移植。结果 :移植过程顺利 ,+ 10天～ + 14天中性粒细胞 >0 .5× 10 9/ L。 + 14天～ + 2 1天血象和骨髓象达 CR。 3例均达嵌合性植入。无移植物抗宿主病。 2例随访 116 d仍健在。 1例 + 5 6 d移植排斥及白血病复发。结论 :非清除性异基因干细胞移植简便、安全、并发症轻 ,对难治性急性白血病有较好疗效。
Objective:To investigated the use of non myloabalative allogeneic peripheral blood stem cells transplantation for refractory or relapsed acute leukemia.Methods:Three patients of refractory or relapsed acute leukaemia with HLA identical siblings were received allogenic peripheral blood stem cells transplant using a non myloabalative conditioning regimen.Results:All of three patients had engraftments of mixed chimerism donor cells and get complete remission without GVHD.Conclusion:These finding indicate the non myloabalative allogeneic peripheral blood stem cells transplantation is much safe,less complications than the myeloablative condioning regimens and may represent another approach in the management of refractory or relapsed acute leukemia.
出处
《白血病》
2000年第4期195-197,共3页
关键词
非清除性预处理
急性白血病
NMA-Allo-PBSCT
Non myloabalative Conditions
Allogeneic stem cells transplantation
Refractory or relapsed acute leukemia
