摘要
研究雄性哺乳动物生殖细胞的增殖、分化、成熟机制以及对以上过程造成影响的诸多因素,为雄性不育症的治疗提供理论依据和潜在的治疗方法,研究人员不断尝试将各种种子细胞诱导为精子。体外诱导精子的实验由于具有可进行连续观察、排除了受体动物的个体差异影响、便于设计单因素实验等优点,近年来取得了许多突破性进展,精原干细胞(spermatagonial stem cell,SSC)、胚胎干细胞(embryonic stem cell,ESC)、诱导性多能干细胞(induced pluripotent stem cell,iPS)、间充质干细胞(mesenchymal stem cell,MSC)等都在体外被成功诱导为精子。就目前的哺乳动物精子体外诱导进展做一综述。
In order to study the mechanisms of proliferation, differentiation and maturation in male mammals’ ge rm cell and the factors which could impact those processes, and find the way to treat male infertility, the researchers tried to induce many kinds of seed cells into sperms. In vitro experiments have advantages such as continuous observation, excluding the effects of individual differences, designing easily single-factor experiment etc. In recent years there are many breakthroughs. Spermatagonial stem cell （SSC）, embryonic stem cell （ESC）, induced pluripotent stem cell （iPS） and mesenchymal stem cell （MSC） has been successfully induced into sperm in vitro. Here, the research progress of mammal sperm induction in vitro were revieued.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2013年第3期135-142,共8页
China Biotechnology
基金
国家自然科学基金(81201762
81272236)
中央高校基本科研业务费(2011JBM294
2010JBZ006)项目资助
