摘要
目的:探讨原发性双侧乳腺癌(bilateral primary breast cancer,BPBC)的临床病理特征及其治疗和预后。方法:回顾分析了2008年6月至2012年9月间郑州大学第一附属医院39例确诊为原发性双侧乳腺癌患者和100例单侧乳腺癌(unilateral breast cancer,UBC)患者的临床病理资料,对比分析单/双侧乳腺癌的临床分期、腋淋巴结状态和病理类型差别。结果:比较单/双侧乳腺癌,非浸润性癌、Tis/T1临床分期在BPBC第二癌/UBC间差异均有统计学意义(P<0.05),其中BPBC第二侧癌所占比例均较高。浸润性导管癌、特殊类型癌在BPBC/UBC间均有统计学差异(P<0.05),其中UBC中浸润性导管癌比例较高,BPBC中特殊类型癌比例较高。浸润性小叶癌发病、腋窝淋巴结转移情况在单/双侧间未见明显差异(P>0.05)。按第二原发癌手术日算起,经过中位25个月的随访,有3例骨转移,1例胸壁复发。结论:对于发病年龄较早、特殊类型癌的双侧乳腺癌患者,单侧发病后更应积极随访以早期检出对侧病变。双侧乳腺癌第二癌早期癌比例较高,为乳腺癌保乳手术提供了条件,但也要高度关注双侧乳腺癌可能潜在较高的恶性程度。
Objective ： To investigate the clinical and pathological characteristics of bilateral primary breast cancer （BPBC） , and the effects on the treatment and prognosis of BPBC. Methods： Medical records of 39 patients diagnosed as BPBC and 100 patients with unilateral breast cancer （UBC） were reviewed at the First affiliated Hospital of Zhengzhou University during the period from June 2008 to September 2012. Data were compared focusing on the clinical stage, lymphatic metastasis ability and pathologic characteristics between the unilateral and bilateral breast carcinoma. Results ： The differences of the proportion of non-invasive cancer and Tis/T1 stage between the second primary breast cancer of BPBC and UBC had statistically significance （P 〈 0.05） , and the proportion of the second cancer of BPBC is higher. There were no significant differences between the UBC and BPBC of invasive lobular breast cancer, lymph nodes status （P 〉 0.05 ） , however differences of invasive ductal carcinoma and special types between them are remarkable （ P 〈 O. 05）. higher proportion of invasive ductal carcinoma were found in UBC and more breast cancer of special types in BPBC. Three patients appeared bone metastasis and one patient relapsed locally during the median 25 months follow-up time. Conclusion： To BPBC patients who have early age and special types, surveillance is necessary to screen the contralateral breast cancer once the primary breast cancer occurred. The second primary breast cancer of BPBC have higher proportion of non-invasive, which make the breast conserving surgery possible. However, it needs more investigations to reveal the potential aggressive features of BPBC.
出处
《河南医学研究》
CAS
2013年第1期20-23,共4页
Henan Medical Research
关键词
双侧原发性乳腺癌
单侧乳腺癌
临床病理
bilateral primary breast cancer
unilateral primary breast cancer
clinicopathological
