奥卡西平混悬液治疗儿童癫痫的疗效及其影响因素被引量：2

下载PDF

导出

摘要目的:观察奥卡西平混悬液治疗儿童癫痫的疗效及其影响因素。方法:回顾性分析21例癫痫患儿资料,分别统计总有效率及幼儿、学龄前儿童两不同组别的有效率,用fisher确切概率法比较两组间率的差异,并用logistic回归分析患儿一般资料对药物疗效的影响。结果:失访4例,自动停药4例,其余13例患儿单药治疗总有效率为61.5%。1例出现过敏现象。幼儿组与学龄前儿童组之间比较有统计学差异(P<0.05)。药物疗效的影响因素分析,P值均>0.05。结论:奥卡西平混悬液治疗儿童癫痫的效果较好;幼儿组的疗效较学龄前儿童稍好;未发现与该药物疗效相关的影响因素。

作者李岩高丽刘艳萍钱小平栾莹孙艳杨柳

机构地区郑州大学第一附属医院儿科河南省人民医院儿科新乡医学院儿科

出处《河南医学研究》 CAS 2013年第1期53-55,共3页 Henan Medical Research

关键词奥卡西平混悬液癫痫儿童疗效影响因素

分类号 R697.3 [医药卫生—泌尿科学]

引文网络
相关文献

参考文献12

1周田,周南,刘峥.奥卡西平口服混悬液与托吡酯治疗癫间疒的开放性研究[J].临床儿科杂志,2011,29(4):375-378. 被引量：5
2Tavassoli A,Ghofrani M,Rouzrokh M,et al.The efficacy and safety ofoxcarbazepine as add-on therapy in intractable epilepsy in children[J].Iranian Journal of Child Neurology,2010,3(4):35-40.
3王治平.癫癇分类和抗癫癇药物的合理应用[J].临床儿科杂志,2008,26(2). 被引量：3
4张丽平,梁东,贾飞勇,陈银波.奥卡西平混悬液治疗儿童癫痫部分性发作的临床研究[J].吉林医学,2011,32(4):684-685. 被引量：3
5Kothare S V,Khurana D S,Mostofi N,et al.Oxcarbazepine mono-therapy in children and adolescents:a single-center clinical experi-ence[J].Pediatr Neurol,2006,35(4):235.
6陈其钻,陈谦学,郭振涛,杨吉安,朱晓楠.奥卡西平单药治疗癫痫间疗效及耐受性的Meta分析[J].卒中与神经疾病,2012,19(5):283-287. 被引量：12
7Beydoun A,Sachdeo R C,Kutluay E,et al.Sustained efficacy andlong-term safety of oxcarbazepine:one-year open-label extension of astudy in refractry partial epilepsy[J].Epilepsia,2003,44(9):1160-1165.
8Agarwal N B,Agarwal N K,Mdeiratta P K,et al.Effect of lamotrigi-ne,oxcarbazepine and topiramate on cognitive functions and oxidativestress in PTZ-kindled mice[J].Seizure,2011,20(3):257-262.
9Coppola G,Franzoni E,Verrotti A,et al.Lvetiracetam or oxcarbaz-epine as monotherapy in newly diagnosed benign epilepsy of childhoodwith centrotemporal spikes(BECT):an open-label,parallelgrouptrial[J].BrainDev,2007,29(5):281-284.
10柴建农.奥卡西平与卡马西平单药治疗新诊断的儿童部分性癫癎对照研究[J].临床儿科杂志,2008,26(8):715-717. 被引量：9

二级参考文献46

1朱曼,孙艳,郭代红,张莉.卡马西平不良反应国内文献分析[J].药物流行病学杂志,2007,16(2):85-87. 被引量：11
2穆莉芳,任尚申,吴春燕,陈英才,郭红.癫痫儿童T细胞免疫功能与其发病因素的相关性分析[J].临床和实验医学杂志,2007,6(9):43-44. 被引量：13
3Schmidt D,Sachdeo R.Oxcarbazepine for treatment of partial epilepsy:A review and recommendations for clinical use[J].Epilpsy Behav,2000,1(6):396.
4Brodie MJ,Kwan P.Staged approach to epilepsy management[J].Neurology,2002,58(8 Suppl 5):S228.
5Barcs G,Walker EB,Elqer CE,et al.Oxcarbazepine,placebo-controlled,dose-ranging,trial,in,refractory,partial,epilepsy[J].Epilepsia,2000,41(12):1597.
6Kothare SV,Khurana DS,Mostofi N,et al.Oxcarbazepi monotherapy in children and adolescents:a single-center clinical experience[J].Pediatr Neurol,2006,35(4):235.
7Schmidt D,Sachdeo R.Oxcarbazepine,for treatment of partial epilepsy:a review and recommendations for clinical use[J].Epilepsy Behav,2000,1(6):396.
8Rey E,Bulteau C,Motte J,et al.Oxcarbazepine pharmacokinetics and tolerability in children with inadequately controlled epilepsy[J].J Clin Pharmacol,2004,44(11):1290.
9Bourgeolis BF,D Souza J.Long-term safety and tolerability of oxcarbazepine in children:a review of clinical experience[J].Epilepsy Behav,2005,7(3):375.
10Franzoni E,Garone C,Sarajlija J,et al.Open prospective study on Oxcarbazepine in epilepsy in children:a preliminary report[J].Seizure,2006,15(5):292.