摘要
目的 :探讨影响喉癌预后的相关因素。方法 :采用免疫组化检测 96例喉鳞状细胞癌标本表达情况 ,并结合临床和病理资料分析喉癌预后因素。结果 :nm2 3、Cath- D和 CD44的阳性表达率分别为45 .7% (43/94)、5 2 .1 % (5 0 /96 )和 41 .7% (40 /96 )。喉癌部位、大小、分化程度、T分期及 nm2 3表达与喉癌颈淋巴结转移有关 (P <0 .0 5 ) ;喉癌的部位、大小、分化程度、分期及颈淋巴结转移与术后 3年生存率有关 (P<0 .0 5 )。结论 :检测 nm2 3在喉癌中表达情况 ,对预测喉癌颈淋巴结转移有一定的参考价值 ;喉癌部位、大小、分化程度。
The gene expression of nm23,Cath D and CD44 were measured by immunohistochemically method in 96 specimens of laryngeal squamous cell carcinoma from 1990 to 1992.There were 92 males and 4 females,ranging in age from 44 to 83 years old.Among 96 patients,35 were supglottic,48 glottic and 13 subglottic,and the clinical stage T 2 in56, T 3,4 in 40.The metastasis rate of survical lymph node was 45 8%(44/96),and the total 3 year survival rate was 79 2%.Results showed that the expression rate of gene nm23,Cath D and CD44 were 45 7%(43/94),52 1%(50/96) and 41 7%(40/96) respectively on 96 cases.There were not relate of these three gene expression positive with the size,stage and histologic grade of cancer.The expression rate of nm23 was 33 3%(14/42) in the group of patients with node metastasis (group A),55 8%(29/52) in the group of patients with negative metastasis (group B)(P<0 05).The expression rate of Cath D was 54 0%(27/50) in group A,37 0%(17/46) in group B (P>0 05);CD44 was 47 5%(19/40) in group A, 44 6%(25/56) in group B(P>0 05).Comparison of the 3 year survival rate of these patients with the site,size,stage,histologic grade and cervical lymph node metastasis were relate (P<0 05),and with these gene expression were not relate (P>0 05).The clinical significance of the expression of nm23,Cath D and CD44 in laryngeal squamous cell carcinoma was discussed in detail.
出处
《耳鼻咽喉（头颈外科）》
2000年第4期219-222,共4页
Chinese Arch Otolaryngology-Head Neck Surg
