摘要
为探讨原发性肝癌患者机体内免疫细胞功能状况以及与肿瘤细胞之间的关系 ,检测了 38例原发性肝癌 ,33例肝炎后肝硬化 ,30例健康对照组血清中白细胞介素 - 8(IL - 8) ,白细胞介素 - 12 (IL - 12 ) ,一氧化氮 (NO)水平。结果表明 :肝硬化组三项指标均显著升高 (P <0 0 5) ,肝癌组IL - 8升高显著 ,IL - 12和NO水平无显著升高 ,认为此与肝癌患者机体内巨噬细胞存在严重功能障碍有关 ,动态检测三项指标对原发性肝癌有辅助诊断价值。
To study the relationship between the functions of immune cells and tumor cells,the levels of interleukin-8(IL-8),interleukin-12(IL-12) and nitric oxide (NO) in sera of 38 patients with primary hepatocellular carcinoma(PHC),33 patients with cirrhosis,30 nomal controls were measured by the ELISA method.It was revealed that the levels of sera IL-8,IL-12,NO in patients with cirrhosis were higher than those in the controls,the levels of IL-12,NO in patients with PHC were in proximity of those in healthy group,but the IL-8 level was significantly higher than that of controls and patients with cirrhosis.These findings suggest that there is severe dysfunction of macrophages in patients with PHC.Dynamic detection of these three markers is helpful to diagnosis of PHC.
出处
《中国医师杂志》
CAS
2000年第8期462-463,共2页
Journal of Chinese Physician
