摘要
目的研究血管性血友病因子(vWF)及P-选择素对狼疮肾炎患者疾病严重程度的评估作用。方法检测我院46例狼疮肾炎患者vWF及P-选择素水平,测量疾病活动指数(SLEDAI)、肾组织活动指数、疾病慢性指数,并与健康体检者进行对比分析。结果纳入狼疮肾炎患者Ⅱ型5例,Ⅲ型12例,Ⅳ型20例,Ⅴ型9例。不同分型的狼疮肾炎患者SLEDAI评分、肾组织活动指数均以Ⅳ型最高,Ⅱ型最低。vWF、P-选择素在Ⅳ及Ⅴ型狼疮肾炎患者中表达水平最高,且与其他两组患者相比差异有统计学意义(P<0.05)。Ⅳ及Ⅴ型患者的vWF及P-选择素水平与对照组比较差异有统计学意义(P<0.05)。相关分析显示vWF与肾组织活动指数呈正相关,与SLEDAI接近相关。P-选择素与肾组织活动指数、疾病慢性指数、SLEDAI呈正相关。结论 vWF及P-选择素提示了狼疮肾炎患者疾病活动性及病变程度,可作为狼疮肾炎患者临床检测指标以指导临床治疗。
Objective To explore the value of yon Willebrand Factor （vWF） and P- selectin in assessing severity of illness in lupus nephritis patients. Methods The level of vWF and P - selectin in 46 cases of lupus nephritis were determined. Disease activity index, renal histological activity index, and disease chronicity index were compared between the study group （ lupus nephritis patients） and the control group （ 10 cases of health checkups） . Results There were 5 cases of type Ⅱ lupus nephritis, 12 cases of type Ⅲ, 20 cases of type Ⅳ, and 9 cases of type Ⅴ. Patients of type Ⅳ lupus nephritis had the highest disease activity index, renal histological activity index, and disease chronic index, while type Ⅱ had the lowest. The expression of vWF and P - selectin in type Ⅳ and Ⅴ lupus nephritis patients were higher than that of type Ⅱ and type Ⅲ（ P 〈 0. 05 ） and that of the control group （ P 〈 0.05 ）. Correlation analysis showed that vWF was positively correlated with renal histological activity index, and nearly correlated with disease activity index. P - selectin was positively correlated with disease activity index, renal histological activity index, and disease chronicity index. Conclusion The expression of vWF and P - selectin indicates disease activity and severity in lupus nephritis patients, therefore can be used as a marker to guide clinical therapy.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第7期758-760,共3页
Chinese General Practice
