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血清Fractalkine和超敏C反应蛋白与早期2型糖尿病肾病的相关性研究 被引量:11

Relationship of Serum Fractalkine and High Sensitivity C-Reactive Protein with Early Type 2 Diabetic Nephropathy
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摘要 目的探讨血清Fractalkine(FKN)和超敏C反应蛋白(hs-CRP)在2型糖尿病正常清蛋白尿期及微量清蛋白尿期(即早期2型糖尿病肾病)的变化及二者与相关代谢指标的相关性。方法选择2009年3月—2010年2月在江苏省中医院内分泌科就诊的139例2型糖尿病患者,根据尿清蛋白/肌酐(UACR)水平,将患者分为正常蛋白尿组(UACR<30 mg/g)92例和微量清蛋白尿组(30 mg/g≤UACR<300 mg/g)47例。收集两组患者的一般资料(包括性别、年龄、病程等);测定相关生化指标水平,计算UACR;采用双抗体夹心酶联免疫(ELISA)法检测血清FKN水平,免疫比浊法测定hs-CRP水平。比较两组患者的各项生化指标及血清FKN、hs-CRP水平,并采用Pearson相关分析和多元逐步回归分析探讨相关指标与血清FKN、hs-CRP水平的关系。结果 (1)正常蛋白尿组和微量清蛋白尿组患者空腹血糖(FBG)、糖化血红蛋白(HbA1c)、hs-CRP水平比较,差异有统计学意义(P<0.01);而两组血脂、FKN水平及肾小球滤过率(eGFR)比较,差异均无统计学意义(P>0.05)。(2)Pearson相关分析显示,血清FKN水平与体质指数(BMI)、腰围、三酰甘油(TG)、hs-CRP均呈正相关(P<0.05)。血清hs-CRP水平与BMI、腰围、eGFR、TG、UACR均呈正相关(P<0.01),与HDL-C呈负相关(P<0.05)。(3)多元逐步回归分析显示,血清FKN与BMI独立相关(β=0.32,P<0.01,R2=0.40);血清hs-CRP与BMI(β=0.30,P<0.01,R2=0.37)、UACR(β=0.17,P<0.01,R2=0.27)独立相关。结论血清FKN水平与早期2型糖尿病患者代谢指标及UACR水平无相关性,而hs-CRP水平与早期2型糖尿病肾病关系密切。 Objective To investigate serum fractalkine (FKN) and high sensitivity C -reactive protein (hs -CRP) levels in normoalbuminuria and microalbuminuria period of type 2 diabetes and analyze the association of fractalkine and hs - CRP with urinary microalbumin excretion. Methods According to urinary albumin - to - creatinine ratio ( UACR), a total of 139 pa- tients with type 2 diabetes in endocrinology department of Jiangsu province hospital of Traditional Chinese Medicine between March 2009 and February 2010 were divided into normoalbuminuria group (UACR 〈30 mg/g, 92 cases) and microalbuminuria group (30 mg/g≤UACR 〈300 mg/g, 47 cases). The basic characteristics of all subjects (including sex, age, courses, etc) were collected. UACR and blood chemistries were determined. FKN and hs - CRP were measured by enzyme - linked immunosorbent as- say (ELISA) and immune turbidimetry respectively. The blood biochemical indices, FKN and hs - CRP levels of the two groups were compared. The relationship of FKN and hs - CRP levels with biochemical indices were analysed using Pearson correlation and multiple stepwise regression methods. Results ( 1 ) Differences of FBG, HbA1e and hs - CRP level between the two groups were statistically significant (P 〈 O. O1 ), while blood lipids, FKN levels and eGFR had no significant differences (P 〉 0. 05 ) (2) FKN was positively correlated with body mass index (BMI) , waist circumference, serum triglyceride and hs - CRP level (P 〈0. 05 ) . The level of hs - CRP was positively related to BMI, waist circumference, eGFR, serum triglyceride and UACR ( P 〈 0. 01 ) and negatively related to HDL - C level ( P 〈 0. 05) . (3) Multiple stepwise linear regression analysis showed that BMI was independently associated with FKN (β=0.32, P〈0. 01, R^2 =0.40); While BMI (β=0.30, P〈0.01, R^2 = 0.37) and UACR (β =0. 17, P 〈0. 01, R^2 = 0. 27) had independent positive correlation with hs- CRP. Conclusion FKN level is not significantly associated with UACR and metabolic index of patients in T2DM. While hs - CRP level is positively correlated with early diabetic nephropathy.
出处 《中国全科医学》 CAS CSCD 北大核心 2013年第9期987-990,共4页 Chinese General Practice
基金 国家"十一五"科技支撑计划重大项目(2006BAI04A03-1)
关键词 FRACTALKINE 超敏C反应蛋白 糖尿病 2型 糖尿病肾病 尿微量清蛋白/肌酐 Fractalkine High sensitivity C - reactive protein Diabetes mellitus, type 2 Diabetic nephropathies Urinary albumin - to - creatinine ratio
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  • 1Gross JL, de Azevedo M J, Silveiro SP, et al. Diabetic nephropathy: diagnosis, prevention, and treatment [ J ]. Diabetes Care, 2005, 28 (1): 164-176.
  • 2Galkina E, Ley K. Leukocyte recruitment and vascular in jury in diabetic nephropathy [J]. J Am Soc Nephrol, 2006, 17 (2) : 368 -377.
  • 3Kshirsagar AV, Bomback AS, Bang H, et al. Association of C - reac- tive protein and microalbuminuria (from the National Health and Nutri- tion Examination Surveys, 1999 to 2004) [J]. Am J Cardiol, 2008, 101 (3) : 401 -406.
  • 4D'Haese JG, Demir IE, Friess H, et al. Fractalkine/CX3CR1 : why a single chemokine - receptor duo bears a major and unique therapeutic po-tential [J]. Expert Opin Ther Targets, 2010, 14 (2): 207-219.
  • 52007年版中国2型糖尿病防治指南[J].中华内分泌代谢杂志,2008,24(2). 被引量:269
  • 6Sampson M J, Drury PL Accurate estimation of glomerular filtration rate in diabetic nephmpathy from age, body weight, and serum creatinine [J]. Diabetes Care, 1992, 15 (5): 609-612.
  • 7American Diabetes Association. Standards of medical care in diabetes-- 2009 [J]. Diabetes Care, 2009, 32 (Suppl 1) : S13 -S61.
  • 8Qatanani M, Lazar MA. Mechanisms of obesity - associated insulin re- sistance: many choices on the menu [J]. Genes Dev, 2007, 21 (12): 1443-1455.
  • 9Mora C, Navarro JF. The role of inflammation as a pathogenic factor in the development of renal disease in diabetes [ J ]. Curr Diab Rep, 2005, 5 (6): 399-401.
  • 10Shah R, Hinkle CC, Ferguson JF, et al. Fraetalkine is a novel human adipochemokine associated with type 2 diabetes [ J ]. Diabetes, 2011, 60 (5): 1512-1518.

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