期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

内脏脂肪素与胰岛素抵抗和动脉粥样硬化的研究进展 被引量：2

Advances in Research on the Role of Visfatin in Insulin Resistance and Atherosclerosis
下载PDF
导出
摘要 内脏脂肪素是近年来发现的主要由内脏脂肪组织表达的一种新型脂肪细胞因子,具有Nampt酶活性,与炎症、内皮功能障碍、血管增生、易损斑块、抗细胞衰老及凋亡、缺血再灌注心肌保护等相关,可能在糖代谢和动脉粥样硬化疾病发生发展中具有重要的作用。 Visfatin, a newly identified adipocytokine, is mainly expressed in visceral adipose tissue. With Nampt enzymatic activity, visfatin is related to inflammation, endothelial dysfunction, angiogenesis, vulnerable plaque, anti-cell senescence or apoptosis or ischemiareperfusion myocardial protection, may play an important role in the progress of glycometabolism or atherosclerosis diseases.
作者 戴青原 郭涛
机构地区 昆明医科大学第一附属医院心内科
出处 《心血管病学进展》 CAS 2013年第2期272-276,共5页 Advances in Cardiovascular Diseases
关键词 内脏脂肪素 胰岛素抵抗 动脉粥样硬化 visfatin insulin resistance atherosclerosis
分类号 R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献24

  • 1Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin [ J ]. Science, 2005,307 ( 5708 ) : 426-430.
  • 2van der Veer E, Ho C, O' Neil C, et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase [ J ]. J Biol Chem, 2007,282 ( 15 ) : 10841-10845.
  • 3van der Veer E, Nong Z, O, Neil C, et al. Pre-B-cell colony-enhancing factor regulates NAD β-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation[ J]. Cire Res, 2005,97( 1 ) :25-34.
  • 4Wang P, Xu TY, Guan YF, et al. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucle- otide[J]. Cardiovasc Res, 2009,81(2):370-380.
  • 5Adya R, Tan BK, Punn A, et al. Visfatiu induces human endothelial VEGF and MMP-2/9 production via MARK and PI3K/Akt signaling pathways: novel insights into visfatin-induced angiogenesis [ J ]. Cardiovasc Res, 2008,78 ( 2 ) : 356-365.
  • 6Borradaile NM, Picketing JG. Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replieative lifespan and enhanced angio- genic capacity in a high glucose environment [ J ]. Aging Cell, 2009,8 ( 2 ) : 100-112.
  • 7Revollo JR, Komer A, Mills KF, et al. Nampt/PBEF/visfatin regulaies insulin secretion in beta ceils as a systemic NAD biosynthetic enzyme[J]. Cell Metab, 2007,6(5 ) :363-375.
  • 8Skop V, Kontrova K, Zfdek V, et al. Autocrine effects of visfatin on hepatocyte sensitivity to insulin action[J]. Physiol Res, 2010,59(4) :615-618.
  • 9Brown JE, Onyango DJ, Ramanjaneya M, et al. Visfatin regulates insulin se- cretion, insulin receptor signaling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells[ J]. J Mol Endocrinol, 2010,44 (3) :171- 178.
  • 10Moschen AR, Kaser A, Enrich B, et al. Visfatin, an adipocytokine with proin- flammatory and immunomodulating properties[ J]. J Immunol, 2007,178(3) : 1748-1758.

二级参考文献10

  • 1BULCAO C, FERREIRA S R, GIUFFRIDA F M, et al. The new adipose tissue and adipocytokines[J]. Curr Diabetes Rev, 2006,2 : 19-28.
  • 2FUKUHARA A, MATSUDA M, NISHIZAWA M. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin[J]. Science, 2005, 307: 426-430.
  • 3KIM S R, BAE S K, CHOI K S, et al. Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase, 1/2[J]. Biochem Biophys Res Commun, 2007, 28: 89-92.
  • 4GOFFREDO G, GENSINI M D. A more meaningful scoring system for determining the severity of coronary heart disease[J]. Am J Cardiol, 1983, 51: 606-607.
  • 5PIGNOLI P, TREMOLI E, POLI A, et al. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imagine[J]. Circulation,1986, 74: 1399-1406.
  • 6CELERMAJER D S, SORENSEN K E, GOOCH V M, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis[J], Lancet, 1992, 540:1111-1115.
  • 7TUVA B D, ARNE Y, MONA S, et al. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis possible role in inflammation and plaque destabilization[J]. Circulation, 2007,115:972-980.
  • 8GEROULAKOS G, GRAVEN T E. The carotid intima-media thickness as a marker of the presence of severe symptomatic coronary artery disease [J]. Eur Heart J,1994,15:781-783.
  • 9ANDERSON T J, UEHETA A, CERHARD M D, et al. Close relation of endothelial function in the human coronary and periphera circulations [J]. J Am Coll Cardiol, 1995, 26:1235-1241.
  • 10姚依群,简文豪,黄小琴,徐少平,徐幼月,吴爱民,朱洁.颈动脉粥样硬化斑块与冠心病[J].中国超声医学杂志,1997,13(9):19-21. 被引量：35

共引文献12

同被引文献25

  • 1浜田紀宏,周吉海,徐杨.内脏脂肪蓄积型肥胖与高尿酸血症[J].日本医学介绍,2006,27(2):75-77. 被引量：21
  • 2中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-419. 被引量：5230
  • 3Wozniak SE, Gee LL, Wachtel MS, et al. Adipose tissue: the new endocnnc organ? A review artlcle[J].Dig Dis, Sci: 1847-1856.
  • 4Fietta P, Delsante G. Focus on adipokines [J]. Theol Biol Forum, 2013,106 ( 1-2 ) : 103-129.
  • 5Barraco GM, Luciano R, Semeraro M, et al. Recently discovered ad- ipokines and cardio-metabolic comorbidities in childhood obesity [J]. Int J Mol Sci, 2014, 15 ( 11 ) : 19760-19776.
  • 6Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin : a protein se- creted by visceral fat that mimics the effects of insulin[J]. Science, 2005, 307(5708) :426-430.
  • 7Kawamoto R, Tomita H, Oka Y, et al. Relationship between serum uric acid concentration, metabolic syndrome and carotid atherosclero- sis[J]. Intern Med, 2006, 45(9) :605-614.
  • 8Krishnan E. Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome : NHANES 2009-2010[J]. J Am Heart Assoc, 2014,3(2) :e000157.
  • 9Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the na- tional cholesterol education program (NCEP) expert panel on detec- tion, evaluation, and treatment of high blood cholesterol in adults ( a- dult treatment panel Ⅲ) [J]. JAMA, 2001, 285(19) :2486-2497.
  • 10Romacho T, Sdnchez-Ferrer CF, Peire C. Visfatin/Nampt : an adi- pokine with cardiovascular impact [J]. Mediators Inflamm, 2013, 2013 : 946427.

引证文献2

二级引证文献4

心血管病学进展
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部