摘要
目的探讨乳腺癌患者外周血清中肺活化趋化因子(CCL18)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)表达水平的关系。方法采用酶联免疫吸附试验(ELISA)检测61例乳腺癌患者血清CCL18、IL-6和TNF-α的表达水平,并以24例乳腺良性病和18例健康体检者做对照,组间水平的比较采用t检验。结果 CCL18、IL-6和TNF-α表达水平在健康体检者组,乳腺良性病组和乳腺癌组血清中依次升高,差异具有统计学意义(P<0.05);三者水平在乳腺癌组随临床分期增加而升高,各期水平的差异有统计学意义(P<0.05)。结论 CCL18、IL-6和TNF-α在乳腺癌中的表达水平密切相关,可以作为判定乳腺癌发展及预后的重要生物学指标。
Objective To investigate the expression relationship of CCL18,IL-6 and TNF-α in peripheral serum in patients with breast cancer.Methods We detected the CCL18,IL-6 and TNF-αexpressions of 61 cases of breast cancer,24 cases of benign breast disease and 18 healthy subjects by ELISA method,and the 24 cases of benign breast disease and 18 healthy subjects were selected as control group.Then compare the difference of expression in each group by t test.Results The expression of CCL18,IL-6 and TNF-αincreased in the healthy subjects group,benign breast disease group and breast cancer group,and the difference was statistically significant（P0.05）;all the three levels increased with the development of clinical period,the difference of the levels in each period was statistically significant（P0.05）.Conclusion The expression of CCL18,IL-6 and TNF-αin breast cancer is closely related,and they can be used as important biological indicators in determining the development and prognosis of breast cancer.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第10期1095-1096,1099,共3页
Chongqing medicine
基金
中国临床肿瘤学科学基金资助项目(Y-L2011-001)
