摘要
背景:脐带间充质干细胞因其具有取材方便、无污染、易扩增、无伦理学差异、多向分化等优点被作为用于组织工程学及再生医学的理想种子细胞。目的:对脐带间充质干细胞的归巢机制进行阐述。方法:以"Umbilicalcordmesenchymalstemcells,homingmechanismorhome,脐带间充质干细胞,归巢机制,归巢特点"为关键词应用计算机检索Pubmed数据库、CNKI数据库2003至2012年,选择内容与脐带间充质干细胞、归巢机制、临床应用相关的文章,这些文献为近期发表或发表在权威杂志,共纳入31篇文献。结果与结论:脐带间充质干细胞的免疫调节、多向分化等优势使其作为一种新的治疗手段应用于临床,使众多疾病的治愈成为可能,其中向缺血或损伤组织炎性归巢的特征是脐带间充质干细胞安全有效的应用于临床的关键。了解脐带间充质干细胞归巢特点,研究其归巢机制,使其高效归巢是脐带间充质干细胞应用于细胞治疗的关键问题。
BACKGROUND： Umbilical cord mesenchymal stem cells have been used as ideal seed cells for tissue engineering and regenerative medicine because of the advantages of easy in harvest, non-pollution, easy amplification, no ethical issues and multi-directional differentiation potential. OBJECTIVE： To review the homing mechanism of umbilical cord mesenchymal stem cells. METHODS： The CNKI database, Wanfang database and PubMed database were searched by computer with key words ＂human umbilical cord mesenchymal stem cells, homing mechanism or home＂ both inEnglish and Chinese for the articles related to umbilical cord mesenchymal stem cells, homing mechanism and clinical applications. All articles were recently published or published in the authorized journals. A total of 31 articles were included. RESULTS AND CONCLUSION： Umbilical cord mesenchymal stem cells have the advantages of immune regulation and multi-directional differentiation, which provide a new treatment method of many diseases, While the characteristic of umbilical cord mesenchymal stem cells homing to ischemic or inflammatory tissue is the key to safe and effective clinical application. Understanding the homing mechanism of umbilical cord mesenchymal stem cells and making an efficient homing of umbilical cord mesenchymal stem cells are important for cell therapy.
出处
《中国组织工程研究》
CSCD
2013年第6期1135-1140,共6页
Chinese Journal of Tissue Engineering Research
关键词
干细胞
干细胞综述
脐带间充质干细胞
归巢特点
归巢机制
干细胞表面标志
肝细胞生长因子
趋化因子
整合素
蛋白酶
免疫调节
组织工程
stem cells
stem cell review
umbilical cord mesenchymal stem cells
homing characteristics
homingmechanism
stem cell surface markers
hepatocyte growth factors
chemokines
integrin
protease
immunomodulation
tissue engineering
