摘要
目的探讨重组人粒细胞集落刺激因子联合地榆升白片改善妇科肿瘤化疗所致白细胞减少症的临床疗效。方法宫颈癌新辅助化疗患者40例随机分为实验组(20例)和对照组(20例);对照组在化疗期间在检测白细胞总数低于正常范围时给予重组人粒细胞集落刺激因子;实验组在此基础上口服地榆升白片。结果 2组患者均在化疗过程中发生白细胞减少,需给予重组人粒细胞集落刺激因子促白细胞上升,但是实验组白细胞总数、中性粒细胞数明显高于对照组,而且需要使用重组人粒细胞集落刺激因子药物的用量也明显减少。结论重组人粒细胞集落刺激因子联合地榆升白片对子宫颈癌患者在新辅助化疗所致的白细胞减少有较好的临床疗效,且未见明显不良反应。
Objective To study the positive clinical effect of the diyushengbai tablet combined with granulocyte colony stimulating factor （G-CSF） on leukopenia caused by gynecological chemotherapy. Methods 40 patients of cervical cancer with neoadjuvant chemotherapy were randomly divided into experiment group （ 20 cases） and control group （20 cases）. The control group were provided with a placebo com- bined with granuloeyte colony stimulating factor when the total leukocyte counts decreasing,while experiment group were treated by the diy- ushengbai tablet combined with granuloeyte colony stimulating factorthe. Results The total leukocyte counts decreased in both 2 groups dur- ing the chemotherapy process and were needed to be given bone marrow hematopoietie promoting drugs such as recombinant human granulo- eyte colony-stimulating factor. The number of patients who needed recombinant human granulocyte colony-stimulating factor in experiment group were less than that of control group. And the needed dosage of recombinant human granulocyte colony-stimulating factor in experiment group was less too. Conclusion Recombinant human granulocyte colony-stimulating factor combined with the diyushengbai tablet has an evi- dently positive influence on leueopenia in the process of the gynecological cancer chemotherapy.
出处
《局解手术学杂志》
2013年第2期165-166,169,共3页
Journal of Regional Anatomy and Operative Surgery
