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鉴别肺癌与肺感染性胸腔积液实验项目的实用性评价 被引量:7

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摘要 目的:评价鉴别肺癌与感染性胸腔积液检查项目的实用性,为合理选择联合检测指标提供科学依据。方法:自动生化分析仪分别测定肺癌和肺感染患者的血清和胸腔积液总蛋白、白蛋白、甘油三酯等生化指标;免疫比浊法测定载脂蛋白(Apo)A、ApoB、转甲状腺素(TTR)蛋白含量;化学发光法测定癌胚抗原(CEA)、神经元特异性烯醇化醇(NSE)和细胞角蛋白19片段(CYRFA21-1)3项肿瘤标志物。同时计算各项生物化学标志物的阳性率与实用性。结果:比较肺癌患者与肺感染患者之间胸腔积液10项非肿瘤标志物与3项肿瘤标志物的含量,发现非肿瘤标志物腺苷脱氨酶(ADA)、TTR和乳酸脱氢酶(LDH)有明显差异,肿瘤标志物CEA、NSE和CYRFA21-1均有显著差异。鉴别肺癌与肺感染胸腔积液,实用性指标顺序为CEA、CYFRA21-1、NSE。结论:首次报道以项目实用性评价鉴别肺癌与肺感染性胸腔积液生物化学标志物,其实用性由高到低顺序为:Glu、ADA、LDH、TTR、CEA、CYFRA21-1、NSE。
出处 《实用医学杂志》 CAS 北大核心 2013年第7期1165-1167,共3页 The Journal of Practical Medicine
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