摘要
目的:探讨HBV感染与TGF-β1和TNF-α的相关性。方法:酶联免疫吸附法(ELISA)检测慢性乙型肝炎患者血清TGF-β1和TNF-α水平;免疫组化法检测乙型肝炎表面抗原(HBsAg)、乙型肝炎核心抗原(HBcAg)、TGF-β1和TNF-α的表达。结果:HBV感染者血清TGF-β1和TNF-α明显高于对照组,差异有统计学意义。肝组织TGF-β1和TNF-α表达明显增强,与非HBV感染组相比,差异有统计学意义。结论:HBV感染与TGF-β1和TNF-α水平密切相关,可以作为诊断和治疗的一个判断指标。
@@@@Objective:To study the levels of TGF-β1,TNF-αand its relationship with hepatitis B(HBV)infection. Method:Serum TGF-β1 and TNF-αlevels were detected by ELISA. The expression of HBsAg,HBcAg,TGF-β1 and TNF-αin liver were detected by immunohistochemical staining. Result:The levels of serum TGF-β1 and TNF-αwere significantly higher in the patients than those in control. The expression of TGF-β1 and TNF-αin liver were significantly higher in the patients with HBV infection than those in control too. Conclusion:The TGF-β1 and TNF-αlevels is closely related to HBV infection. So detection of serum TGF-β1 and TNF-αlevels might be of prognostic importance in patients with chronic hepatitis B as high levels of these cytokines might favor malignant changes.
出处
《中国医学创新》
CAS
2013年第9期3-5,共3页
Medical Innovation of China
