摘要
脱氧雪腐镰刀菌烯醇(deoxynivalenol,DON)是谷物及谷物产品中最常见的一种真菌毒素,其主要通过激活丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)等细胞信号转导通路以及线粒体介导细胞凋亡途径而发挥免疫毒性作用——抑制蛋白质合成、诱导细胞凋亡、损伤肠道和抑制机体免疫等,对人和动物的健康造成了巨大的影响。综述了DON对机体肠道的组织形态、屏障功能的损伤,及其对肠道相关细胞、黏膜免疫球蛋白的分泌、细胞因子的表达和肠道微生物平衡的影响,并进一步阐述了其作用机理,以期为DON的研究提供参考。
Deoxynivalenol （DON） is one of the most common fungus mycotoxin in cereal grains and cereal products. It plays a significant role in inhibiting protein synthesis, inducing cells apoptosis and deteriorating intestinal tract through activating mitogen-activated protein kinases （MAPKs） or mitochondria-mediated cell apoptosis pathways, resulting in serious impairment of the health of animals and human beings. In this article, the effects of DON on the intestinal histological morphology and intestinal barrier functions, intestinal cells, immunoglobulin secretion and cytokine expression, the balance of intestinal microbial, as well as its underlying mechanism of action, were reviewed.
出处
《生命科学》
CSCD
2013年第4期402-409,共8页
Chinese Bulletin of Life Sciences
基金
湖南省自然科学基金项目(12JJ2020)
国家自然科学基金项目(31072042)
国家重点基础研究发展计划("973"项目)(2009CB118806)
