摘要
目的:研究黄芩素滴丸对大鼠的急性毒性。方法:实验分为对照(等容纯化水)与黄芩素滴丸高、中、低剂量(1.0、0.5、0.25g/kg)组。灌胃给药,每天1次,连续12周。测定给药12周和停药4周后大鼠各项指标。结果:在12周给药期间,黄芩素滴丸高、中、低剂量组大鼠一般状况良好,行为活动正常,无异常外观体征,大鼠排尿、排便、饮水、摄食量及一般体征与对照组比较无显著性差异。给药12周后,黄芩素滴丸中剂量组血红蛋白显著高于对照组(P<0.05),血糖、总胆红素显著低于对照组(P<0.01或P<0.05)。停药4周后,黄芩素滴丸高剂量组总蛋白显著低于对照组(P<0.05)。结论:黄芩素滴丸在1.0、0.5、0.25g/kg剂量下连续给药12周,对大鼠排尿、排便、饮水、摄食量、血常规、尿常规、血液生化学指标无明显影响。
OBJECTIVE： To study on acute toxicity of Baicalin dripping pills on rats. METHODS： The experimental rats were divided into control group （constant volume of purified water）, Baicalein dripping pills high-dose, medium-dose and low-dose groups （1, 0.5, 0.25 g/kg）. They were given medicines intragastrically once a day, for 12 consecutive weeks. The indexs were tesed after 12 weeks of administration and 4 weeks after drug withdrawal .RESULTS： During 12 weeks, rats of Baicalein dripping pills high-dose, medium-dose and low-dose groups were in good condition, and the activities of them were normal without abnormal signs and appearance. There was no significant difference in defecation, urination, drinking water, food and general symptoms between high-dose, medium-dose and low-dose groups and control group. Compared with control group, HGB in Baicalein dripping pills medium-dose groups increased significantly（P〈0.05）,Glu and TBili decreased significantly（P〈0.01,P〈0.05）after 12 weeks of administration. TP in Baicalein dripping pills high-dose groups decreased significantly（P〈0.05）4 weeks after drug withdrawal. CONCLUSION： Baicalein dripping pills 1, 0.5 and 0.25 g/kg have no obvious effect on the urination, defecation, drinking water and food intake after 12 weeks continuous administration.
出处
《中国药房》
CAS
CSCD
2013年第15期1356-1359,共4页
China Pharmacy
基金
天津市科学技术重点攻关项目(No.033180311)
关键词
黄芩素
滴丸
口服给药
生化指标
Baicalein
Dripping pills
Oral administration
Biochemical index
