摘要
目的分析2007-2010年ICU嗜麦芽寡养单胞菌的临床分布及耐药变迁分析,为合理使用抗菌药物提供依据。方法采用回顾性调查分析2007-2010年ICU嗜麦芽寡养单胞菌533株,药敏试验采用K-B纸片扩散法。结果 4年来嗜麦芽寡养单胞菌标本检出率和15种抗菌药物耐药率总体呈上升趋势,检出率由2007年3.69%上升至2010年4.14%,痰液标本来源最高,>70.00%;对哌拉西林/他唑巴坦的敏感性最好,耐药率<15.00%,对头孢哌酮/舒巴坦及左氧氟沙星有较好的敏感性,对头孢吡肟耐药率上升明显,由2008年11.20%上升至2010年46.10%。结论嗜麦芽寡养单胞菌是ICU医院感染常见条件致病菌之一,检出率和耐药率呈逐年上升趋势,因此合理、规范使用抗菌药物和加强各种防护措施,是有效防止该菌的耐药率增高和多药耐药菌产生的关键。
OBJECTIVE To study the clinical distribution and drug resistance of Stenotrophomonas rnaltophilia in the ICU from 2007 to 2010 so as to provide the theoretical basis for rational use of antimicrobial agents. METHODS Retrospective analyses were performed on the results of drug susceptibility testing for 533 strains of S. maltophilia during the past four years. Antimicrobial susceptibility testing was performed by using Kirb-Bauer method. RESULTS The detection rate as well as the resistance rate of S. maltophilia to 15 antibiotics kept an upward trend in the 4 years. The sputum specimens was dominant in the specimens sources, accounting for more than 70.00%, the detection rate increased from 3. 69% in 2007 to 4. 14% in 2010. The strains were most susceptible to piperacillin/tazobactam with the drug resistance less than 15. 00% and were highly sensitive to cefoperazone/sulbactam and levofloxacin, the drug resistance rate to cefepime was increased significantly, increas- ing from 11. 20% in 2008 to 46. 10% in 2010. CONCLUSION S. malto＇philia is one of the common species of pathogens causing opportunistic nosocomial infections, the detection rate as well as the resistance rate keeps an upward tendency, therefore, it is crucial to reasonably use antibiotics and strengthen the prevention measures so as to effectively prevent the increasing drug resistance rate and the emergence of the multidrug-resistant strains.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第7期1701-1703,共3页
Chinese Journal of Nosocomiology
