摘要
为探讨益生菌口服对结肠癌患者术前肠道准备及术后应激状况和免疫功能的影响，将60例拟行手术治疗的结肠癌患者随机分为观察组和对照组，各30例，两组患者术前均应用聚乙二醇溶液口服进行快速肠道准备，观察组肠道准备前加服益生菌，2g／d，至少5d；对照组不加服益生菌。比较两组患者的肠道清洁情况、术后应激状况及免疫功能。结果显示，（1）肠道清洁度：观察组肠道清洁有效率为96．7％（29／30），对照组为76．7％（23／30），两组差异有统计学意义，P〈0．05。（2）术后应激状况：观察组术后次日疼痛评分显著低于对照组，P〈0．05；术后首次胃肠道排气时间、首次下床活动时问、术后第7天C反应蛋白含量均明显少于对照组，P〈0．05。（3）术后免疫功能：观察组术后第7天CD4＋、CD4＋／cD8＋、IgM、IgG均显著高于对照组，PG0．05。结果表明，术前口服益生菌能够增加结肠癌患者的肠道清洁度，降低患者术后应激反应，改善患者的免疫功能。
In order to explore the influence of probiotics on preoperative bowel preparation, postoperative stress situation and immune function of colorectal cancer patients,the 60 cases to be subjected to surgical treatment were randomly divided into observation and control groups, at preoperation all cases of both groups were orally adminitered with macrogol solution for rapid bowel preparation but observation group added with probiotics （2g/d, for 5 days at least） then the clean situation of bowel, postoperative stress sit- uation and immune function of both groups were compared. As results, 1）on bowel clean degree, the effec- tive rate in observation group was 96.7%（29/30）, in control group, 76.7 % （23/30）, there was statistical difference（ P 〈0.05）;2）on postoperative stress,in pain score rating on the first day after operation,gas- tro-intestinal flatus at first time,time for ambulation at first time,and the level of C-reactive protein on the 7th day,observation group was all lower or less than control group significantly （ P 〈0.05） ;3）on postop- erative immune function,on the 7th day the levels of CD4＋, CD4＋/CD8＋ , IgM, IgG in observation group were significantly higher than control group （ P 〈0.05）. Results show that oral administration of probiot- ics before operation can increase bowel clean degree, improve immune function of patients. decrease postoperative stress situation of patients, and
出处
《中国肛肠病杂志》
2013年第2期13-15,共3页
Chinese Journal of Coloproctology
关键词
益生菌
结肠癌
肠道准备
术后应激
免疫功能
Probiotics
Colon cancer
Bowel preparation
Postoperative stress
Immune function
