摘要
目的了解玉林市孕妇唐氏综合征高风险状况并提出干预措施,为玉林市政府部门制定预防出生缺陷措施提供决策依据。方法于2012年4月1日至2012年10月31日对33571例孕妇于怀孕15～20+6周抽取静脉血,采用时间分辨荧光法定量测定孕妇血清中甲胎旦白(hAFP)和游离β绒毛膜促性腺素(Free HCGβ),结合孕妇年龄、体重、孕周、病史等,通过计算机软件计算出风险系数,对高风险孕妇建议胎儿染色体诊断分析。结果 33571例孕妇自愿接受唐氏综合征筛查,筛出高风险孕妇1167例,筛查阳性率3.48%(1167/33571)。其中接受产前诊断444例,产前诊断率38.05%(444/1167)。确诊4例唐氏综合征胎儿,检出率为0.90%(4/444),均终止了妊娠。结论对孕妇大范围唐氏综合征高风险筛查,筛出高危孕妇进一步产前诊断是预防唐氏综合征活产的有效措施。
Objective To understand the high risk situation of Down＇s syndrome in Yulin pregnant women, and propose interventions. Methods 33 571 pregnant women during April 1, 2012 to October 31, 2012 were taken venous blood at 15 - 20＋6 weeks of pregnancy, and the time resolved luminescence was used to quantitatively detect the Alpha-fetoprotein （hAFP） and Free HCG ft. The risk priority number was calculated by computer combined with maternal age, weight, gestational age, medical history, etc. Chromosome diagnostic analysis was taken in pregnant women with high-risk factor. Results 33 571 cases had accept the Down＇s syndrome screening voluntarily, and 1 167 cases were screened out, with the positive rate of 3.48%. 444 cases had prenatal diagnosis （38.05%, 444/1 167）, and 4 cases of Down＇s syndrome fetus were diagnosed （0.90%, 4/444）. Conclusions Wide range high-risk screening of Down＇s syndrome among pregnant women, and further prenatal diagnosis for high-risk pregnant women screening are the effective measures for prevention of live births with Down＇s syndrome.
出处
《临床医学工程》
2013年第3期374-375,共2页
Clinical Medicine & Engineering
基金
玉林市科技攻关项目(项目编号:玉市科攻12073009)
关键词
孕妇
唐氏综合征
产前筛查
产前诊断
Pregnant women
Down＇s syndrome
Prenatal screening
Prenatal diagnosis
